Kort Sheila, Wickliffe Jeffrey, Shankar Arti, Covert Hannah H, Lichtveld Maureen, Zijlmans Wilco
Faculty of Medical Sciences, Anton de Kom University of Suriname, P.O. Box 9212 Paramaribo, Suriname.
Department of Environmental Health Sciences, School of Public Health, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
J Xenobiot. 2024 Aug 1;14(3):1051-1063. doi: 10.3390/jox14030059.
Exposure to mercury (Hg) and lead (Pb), in combination with liver and kidney impairment, may result in adverse birth outcomes. From 408 women in the age range of 16 to 46 years, living in rural and urban areas in the interior of Suriname, we looked at the association between adverse birth outcomes and exposure to Hg and Pb in combination with liver and kidney function. This group of women represented a subcohort of pregnant women who participated in the Caribbean Consortium for Research in Environmental and Occupational Health (CCREOH)-Meki Tamara study. Liver function was assessed by measuring aspartate amino transferase (AST), alanine amino transferase (ALT), and gamma-glutamyl transferase (GGT). Kidney function was assessed by measuring creatinine, urea, and cystatin C. We defined preterm births as birth before 37 weeks of gestation, low birthweight as birthweight < 2500 g, and low Apgar score as a score < 7 at 5 min, and these were used as indicators for adverse birth outcomes. Small size for gestational age was defined as gestational age < -2SD weight for GA. We found significant statistical associations between biomarkers for liver and kidney functions and adverse birth outcomes Apgar score and gestational age. No significant association was found between heavy metals Hg and lead and adverse birth outcomes.
接触汞（Hg）和铅（Pb），再加上肝肾功能损害，可能会导致不良分娩结局。我们对苏里南内地城乡地区408名年龄在16至46岁之间的女性进行研究，观察不良分娩结局与接触汞和铅并伴有肝肾功能之间的关联。这组女性代表了参与加勒比环境与职业健康研究联盟（CCREOH）-梅基·塔玛拉研究的孕妇亚队列。通过测量天冬氨酸氨基转移酶（AST）、丙氨酸氨基转移酶（ALT）和γ-谷氨酰转移酶（GGT）来评估肝功能。通过测量肌酐、尿素和胱抑素C来评估肾功能。我们将早产定义为妊娠37周前分娩，低出生体重定义为出生体重<2500克，低阿氏评分定义为5分钟时评分<7分，这些被用作不良分娩结局的指标。小于胎龄儿定义为胎龄< -2SD（根据胎龄计算的体重标准差）。我们发现肝肾功能生物标志物与不良分娩结局阿氏评分和胎龄之间存在显著的统计学关联。未发现重金属汞和铅与不良分娩结局之间存在显著关联。
