治疗前和治疗后[18F]FDG PET/CT 在接受化疗和放疗的口咽鳞癌患者中的预后作用。
Prognostic Role of Pre- and Post-Treatment [18F]FDG PET/CT in Squamous Cell Carcinoma of the Oropharynx in Patients Treated with Chemotherapy and Radiotherapy.
机构信息
Nuclear Medicine, Università degli Studi di Brescia and ASST Spedali Civili di Brescia, 25123 Brescia, Italy.
Nuclear Medicine, ASL Bari-P.O. Di Venere, 70012 Bari, Italy.
出版信息
Med Sci (Basel). 2024 Jul 29;12(3):36. doi: 10.3390/medsci12030036.
BACKGROUND
The prognostic role of imaging with [18F]fluorodeoxyglucose ([18F]FDG) positron emission tomography/computed tomography (PET/CT) in oropharynx cancer (OPC) has been demonstrated in the past. The aim of this study was to assess the prognostic impact of both baseline and post-treatment PET/CT in patients with OPC and treated with chemo- and/or radiotherapy.
METHODS
The PET/CT parameters of scans performed before and after therapy were collected and analyzed to find significant prognosticators for progression-free survival (PFS) and overall survival (OS). Human papillomavirus (HPV) infection's influence on the prognosis was also taken into account.
RESULTS
A total of 66 patients were included in the study. The staging volumetric parameters of PET/CT were significant prognosticators for OS, while the same parameters were affordable predictors for PFS at the restaging evaluation. No significant correlations between HPV infection and PET/CT parameters were reported.
CONCLUSION
The prognostic role of volumetric [18F]FDG PET/CT parameters in patients with OPC was reported.
背景
过去已经证明，[18F]氟脱氧葡萄糖([18F]FDG)正电子发射断层扫描/计算机断层扫描(PET/CT)成像在口咽癌(OPC)中的预后作用。本研究的目的是评估在接受放化疗治疗的 OPC 患者中，基线和治疗后 PET/CT 的预后影响。
方法
收集并分析治疗前后扫描的 PET/CT 参数，以找到无进展生存期(PFS)和总生存期(OS)的显著预后因素。还考虑了人乳头瘤病毒(HPV)感染对预后的影响。
结果
共有 66 例患者纳入研究。PET/CT 的分期容积参数是 OS 的显著预后因素，而在重新分期评估时，相同的参数是 PFS 的可负担预测因素。HPV 感染与 PET/CT 参数之间无显著相关性。
结论
报告了 OPC 患者中容积[18F]FDG PET/CT 参数的预后作用。
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