Capo V, Ozzello L, Fenoglio C M, Lombardi L, Rilke F
Hum Pathol. 1985 Feb;16(2):144-50. doi: 10.1016/s0046-8177(85)80063-0.
Immunostaining for Factor VIII-related antigen was seen in deparaffinized sections from 19 of 20 postmastectomy angiosarcomas and from four of four sarcomas that arose in chronically edematous tissue unrelated to breast carcinoma. Staining was also seen in sections from two malignant hemangioendotheliomas, four capillary hemangiomas, and one granulation tissue specimen. Sections from two lymphangiomas were immunonegative for Factor VIII-related antigen in the endothelium of lymphatic channels, whereas staining was observed in the surrounding normal blood vessels. Electron microscopic study of four postmastectomy angiosarcomas disclosed ultrastructural features (fenestrae, intense pinocytotic activity, cell junctions, and Weibel-Palade bodies) supporting the blood vascular endothelial nature of the neoplastic cells. It is concluded that a neoplastic blood vessel component is present in sarcomas that arise in chronically edematous tissues. It is questionable whether a lymphatic component is also present. These tumors, therefore, should be regarded as angiosarcomas rather than lymphangiosarcomas.
在20例乳房切除术后血管肉瘤中的19例以及4例发生于与乳腺癌无关的慢性水肿组织中的肉瘤的石蜡切片中，均可见到VIII因子相关抗原免疫染色。在2例恶性血管内皮瘤、4例毛细血管瘤及1例肉芽组织标本的切片中也可见到染色。2例淋巴管瘤的切片中，淋巴管内皮细胞对VIII因子相关抗原免疫阴性，而在周围正常血管中可见染色。对4例乳房切除术后血管肉瘤进行电镜研究，发现超微结构特征（窗孔、活跃的胞饮作用、细胞连接及魏-帕小体）支持肿瘤细胞的血管内皮性质。结论为，发生于慢性水肿组织中的肉瘤存在肿瘤性血管成分。是否也存在淋巴管成分尚存在疑问。因此，这些肿瘤应视为血管肉瘤而非淋巴管肉瘤。
