Department of Gynaecology, Jinan Maternity and Child Care Hospital, Jinan, Shandong, P.R. China.
Cancer Invest. 2024 Sep;42(8):726-739. doi: 10.1080/07357907.2024.2395014. Epub 2024 Aug 27.
The role of tweety homolog 3 (TTYH3) has been studied in several cancers, including hepatocellular carcinoma, cholangiocarcinoma, and gastric cancer. The results showed that TTYH3 is highly expression in cervical cancer tissues and cells and high TTYH3 expression correlates with poor prognosis in patients with cervical cancer. TTYH3 markedly reduced the apoptosis rate and promoted proliferation, migration, and invasion. Silencing of TTYH3 has been shown to have an inhibitory effect on cervical cancer progression. Moreover, TTYH3 enhanced EMT and activated Wnt/β-catenin signaling. Furthermore, TTYH3 knockdown inhibited the tumor growth in vivo. In conclusion, TTYH3 promoted cervical cancer progression by activating the Wnt/β-catenin signaling.
Tweety 同源物 3（TTYH3）的作用在几种癌症中进行了研究，包括肝细胞癌、胆管癌和胃癌。结果表明，TTYH3 在宫颈癌组织和细胞中高度表达，高表达 TTYH3 与宫颈癌患者预后不良相关。TTYH3 明显降低了细胞凋亡率并促进了增殖、迁移和侵袭。沉默 TTYH3 已被证明对宫颈癌的进展具有抑制作用。此外，TTYH3 增强了 EMT 并激活了 Wnt/β-catenin 信号通路。此外，TTYH3 敲低抑制了体内肿瘤生长。总之，TTYH3 通过激活 Wnt/β-catenin 信号通路促进了宫颈癌的进展。
