Division of Perinatology, Department of Obstetrics and Gynecology, Mersin University Faculty of Medicine, Mersin, Turkey.
Division of Perinatology, Department of Obstetrics and Gynecology, Necmettin Erbakan University Faculty of Medicine, Konya, Turkey.
J Clin Ultrasound. 2024 Nov-Dec;52(9):1321-1328. doi: 10.1002/jcu.23804. Epub 2024 Aug 27.
In our study, we aimed to investigate the value of fetal epicardial fat thickness (EFT) and modified myocardial performance index (mod-MPI) in fetal growth restriction (FGR) that develops after the 32nd week of gestation.
Fifty-six pregnant women who met the inclusion and exclusion criteria were included in the study and were divided into two groups: pregnancies diagnosed with FGR after the 32nd week of gestation (FGR group) and those without (control group). Demographic and obstetric histories, ultrasonographic and clinical characteristics, fetal EFT and mod-MPI values, and neonatal outcomes of the groups were recorded, and comparisons were made between the groups. Additionally, the diagnostic performance of fetal EFT value in late FGR was investigated.
The FGR group had fetal EFT that was statistically significantly lower (1.11 ± 0.21 vs. 1.34 ± 0.23, p = 0.001). The FGR group had a significantly lower isovolumetric contraction time (ICT) (31.04 ± 6.88 vs. 35.14 ± 7.58, p = 0.048). The two groups' isovolumetric relaxation time (IRT), ejection time (ET), and mod-MPI values (p values 0.871, 0.55, and 0.750, respectively) were comparable. Receiver operating characteristic (ROC) analysis at a cutoff of 1.2 revealed 76.1% sensitivity and 74.2% specificity, respectively, for the diagnostic performance of the fetal EFT value in late-onset FGR. There was a positive predictive value (PPV) and negative predictive value (NPV) of 64.0% and 83.8%, respectively.
We found that fetal EFT was significantly lower in FGR and may be useful in diagnosing FGR. However, we observed that mode-MPI did not change in FGR.
在本研究中，我们旨在探讨孕 32 周后发生的胎儿生长受限（FGR）中胎儿心外膜脂肪厚度（EFT）和改良心肌做功指数（mod-MPI）的价值。
将符合纳入和排除标准的 56 名孕妇纳入研究，并分为两组：孕 32 周后诊断为 FGR 的孕妇（FGR 组）和无 FGR 的孕妇（对照组）。记录两组的人口统计学和产科病史、超声和临床特征、胎儿 EFT 和 mod-MPI 值以及新生儿结局，并进行组间比较。此外，还研究了胎儿 EFT 值在晚期 FGR 中的诊断性能。
FGR 组胎儿 EFT 明显较低（1.11±0.21 比 1.34±0.23，p=0.001）。FGR 组等容收缩时间（ICT）明显较短（31.04±6.88 比 35.14±7.58，p=0.048）。两组的等容舒张时间（IRT）、射血时间（ET）和 mod-MPI 值（p 值分别为 0.871、0.55 和 0.750）无显著差异。EFT 值诊断晚期 FGR 的截断值为 1.2 时，灵敏度和特异度分别为 76.1%和 74.2%。阳性预测值（PPV）和阴性预测值（NPV）分别为 64.0%和 83.8%。
我们发现 FGR 组胎儿 EFT 明显降低，可能有助于诊断 FGR。然而，我们观察到 FGR 组的 mod-MPI 没有改变。
