Novel candidates synthesis of indenopyrazole, indenoazine and indenothiophene, with anticancer and studies.

The indandione nucleus, is one of the most amazing nuclei in medicinal chemistry, is used to design new derivatives. Novel indandione derivatives are prepared with different electrophilic and nucleophilic reagents to yield , , , , , and . Compounds and are investigated against OVCAR-3 and HeLa, using LLC-MK2 and -Pt as references. and spectral studies were analyzed for the selected compounds. Compounds and at 100 ns were the most potent compounds, so molecular dynamics studies were performed. Compound was the most active toward the HeLa cervical cell line, and compound was the most active toward the Ovcar-3 cell line.