School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, China.
Langmuir. 2024 Sep 10;40(36):19125-19133. doi: 10.1021/acs.langmuir.4c02245. Epub 2024 Aug 27.
Chemodynamic therapy is an appealing modality in cancer treatment. However, its therapeutic effectiveness is impeded by insufficient catalytic efficiency and overexpression of glutathione (GSH) at the tumor site. In this study, a poly(-phenylenediamine) (PoPD)@copper sulfide (CuS) nanoplatform was developed as dual-level reactive oxygen species (ROS) amplifier for enhanced photothermal-chemodynamic therapy. The PoPD@CuS nanoplatform exhibited photothermal performance, chemodynamic performance, and GSH-depleting capability. Alongside its improved photothermal conversion efficiency with tumor pH-responsiveness, the photothermal behavior of PoPD@CuS could elevate chemodynamic activity by regulating the temperature spatiotemporally, leading to increased ROS production. Moreover, GSH depletion of PoPD@CuS could suppress ROS scavenging, further enhancing oxidative stress in the tumor region. Consequently, functioning as a dual-level ROS amplifier, PoPD@CuS showcased remarkable effectiveness in photothermal-chemodynamic combination therapy.
化学动力学疗法在癌症治疗中具有吸引力。然而，其治疗效果受到肿瘤部位催化效率不足和谷胱甘肽 (GSH) 过表达的阻碍。在本研究中，开发了一种聚（苯二胺）（PoPD）@硫化铜（CuS）纳米平台，作为双级活性氧（ROS）放大器，以增强光热-化学动力学治疗。PoPD@CuS 纳米平台表现出光热性能、化学动力学性能和 GSH 耗竭能力。PoPD@CuS 的光热行为通过时空调节温度来提高化学动力学活性，从而增加 ROS 的产生，同时提高了肿瘤 pH 响应的光热转换效率。此外，PoPD@CuS 的 GSH 耗竭可以抑制 ROS 清除，进一步增强肿瘤区域的氧化应激。因此，作为双级 ROS 放大器，PoPD@CuS 在光热-化学动力学联合治疗中表现出显著的疗效。
