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谷胱甘肽消耗型双金属纳米炸弹联合光热和化学动力学治疗肿瘤：体内外研究。

A Glutathione-Consuming Bimetallic Nano-Bomb with the Combination of Photothermal and Chemodynamic Therapy for Tumors: An in vivo and in vitro Study.

机构信息

Department of Endocrinology and Metabolism, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People's Republic of China.

Department of Pathology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People's Republic of China.

出版信息

Int J Nanomedicine. 2024 Aug 21;19:8541-8553. doi: 10.2147/IJN.S465480. eCollection 2024.

DOI:10.2147/IJN.S465480
PMID:39185347
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11345010/
Abstract

BACKGROUND

Chemodynamic therapy (CDT) faces challenges of low catalytic ion efficiency and ROS production. We developed a ROS nano-bomb, Cu/ZIF-8@GA-Fe, to address these issues.

METHODS

The nano-bomb was synthesized by doping copper into ZIF-8 and assembling Fe and gallic acid (GA). It was tested for reactive oxygen species (ROS) generation in acidic conditions and its photothermal properties.

RESULTS

In an acidic micro environment, Cu/ZIF-8@GA-Fe effectively released Fe and Cu, depleting GSH and generating ROS. The GA-Fe coating provided photothermal heat and was used to enhance Fenton reactions via dual ions for increasing ROS production. In vivo and in vitro experiments, Cu/ZIF-8@GA-Fe inhibited tumor growth with minimal side effects.

CONCLUSION

Cu/ZIF-8@GA-Fe shows promise for safe and effective CDT, offering a synergistic approach to tumor therapy.

摘要

背景

化学动力学疗法（CDT）面临催化离子效率和 ROS 生成低的挑战。我们开发了一种 ROS 纳米炸弹 Cu/ZIF-8@GA-Fe 来解决这些问题。

方法

通过将铜掺杂到 ZIF-8 中并组装铁和没食子酸（GA）合成了纳米炸弹。在酸性条件下测试了它产生活性氧（ROS）的能力及其光热性能。

结果

在酸性微环境中，Cu/ZIF-8@GA-Fe 有效地释放铁和铜，耗尽 GSH 并产生 ROS。GA-Fe 涂层提供光热热量，并通过双离子用于增强芬顿反应以增加 ROS 生成。在体内和体外实验中，Cu/ZIF-8@GA-Fe 抑制肿瘤生长，副作用极小。

结论

Cu/ZIF-8@GA-Fe 为安全有效的 CDT 提供了前景，为肿瘤治疗提供了一种协同方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/94cb/11345010/8e9d6287acf8/IJN-19-8541-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/94cb/11345010/1a84d2b8d2e4/IJN-19-8541-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/94cb/11345010/1c8f60e57b0f/IJN-19-8541-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/94cb/11345010/dc4e7b7b7638/IJN-19-8541-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/94cb/11345010/8023bc8f1f2e/IJN-19-8541-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/94cb/11345010/a3dd1af8c835/IJN-19-8541-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/94cb/11345010/8e9d6287acf8/IJN-19-8541-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/94cb/11345010/1a84d2b8d2e4/IJN-19-8541-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/94cb/11345010/1c8f60e57b0f/IJN-19-8541-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/94cb/11345010/dc4e7b7b7638/IJN-19-8541-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/94cb/11345010/8023bc8f1f2e/IJN-19-8541-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/94cb/11345010/a3dd1af8c835/IJN-19-8541-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/94cb/11345010/8e9d6287acf8/IJN-19-8541-g0006.jpg

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