甲状腺素结合蛋白的家族性异常：一些识别与解读的问题。
Familial abnormalities of thyroxine binding proteins: some problems of recognition and interpretation.
作者信息
Neild J E, Byfield P G, Lalloz M R, Tait D, Marigold J H, Croft D N, Slavin B M
出版信息
J Clin Pathol. 1985 Mar;38(3):327-30. doi: 10.1136/jcp.38.3.327.
A three generation family study was carried out after inappropriate treatment with radioactive iodine of a 50 year old woman with a raised serum total thyroxine concentration and free thyroxine index. Subsequent investigations showed that she and five members of her family had raised thyroxine binding globulin concentrations. Free thyroxine and free triiodothyronine concentrations were normal. Problems encountered in the recognition of this thyroxine binding protein disorder are discussed. Clinicians and clinical biochemists should be aware of these pitfalls and thus avoid further incorrect treatment on the basis of biochemical findings, even though free hormone estimations are now becoming readily available.
对一名血清总甲状腺素浓度和游离甲状腺素指数升高的50岁女性进行放射性碘不适当治疗后，开展了一项三代家系研究。后续调查显示，她及其家族中的五名成员甲状腺素结合球蛋白浓度升高。游离甲状腺素和游离三碘甲状腺原氨酸浓度正常。文中讨论了在识别这种甲状腺素结合蛋白紊乱时遇到的问题。临床医生和临床生物化学家应意识到这些陷阱，从而避免基于生化检查结果进行进一步的错误治疗，尽管现在游离激素检测已很容易获得。
Zotero 插件