Faculty of Medicine Health and Human Sciences, Macquarie University, North Ryde, NSW, 2109, Australia.
Save Sight Institute, Sydney University, Sydney, NSW, 2000, Australia.
Aging Dis. 2024 Oct 1;15(5):2149-2167. doi: 10.14336/AD.2024.03019.
A prominent feature in many neurodegenerative diseases involves the spread of the pathology from the initial site of damage to anatomically and functionally connected regions of the central nervous system (CNS), referred to as transsynaptic degeneration (TSD). This review covers the possible mechanisms of both retrograde and anterograde TSD in various age-related neurodegenerative diseases, including synaptically and glial mediated changes contributing to TDS and their potential as therapeutic targets. This phenomenon is well documented in clinical and experimental studies spanning various neurodegenerative diseases and their respective models, with a significant emphasis on the visual pathway, to be explored herein. With the increase in the aging population and subsequent rise in age-related neurodegenerative diseases, it is crucial to understand the underlying mechanisms of.
许多神经退行性疾病的一个显著特征是，病理学从最初的损伤部位传播到中枢神经系统（CNS）在解剖和功能上相连的区域，这被称为突触后退行性变（TSD）。这篇综述涵盖了各种与年龄相关的神经退行性疾病中逆行和顺行 TSD 的可能机制，包括对 TDS 有贡献的突触和神经胶质介导的变化及其作为治疗靶点的潜力。这一现象在跨越各种神经退行性疾病及其各自模型的临床和实验研究中得到了很好的记录，本文将重点探讨视觉通路。随着老年人口的增加和随之而来的与年龄相关的神经退行性疾病的增加，了解其潜在机制至关重要。
