H-2Dd和H-2Ld组织相容性抗原的差异表达。
Differential expression of H-2Dd and H-2Ld histocompatibility antigens.
作者信息
Weis J H, Murre C
出版信息
J Exp Med. 1985 Feb 1;161(2):356-65. doi: 10.1084/jem.161.2.356.
Abstract
To determine why the H-2Dd antigen is expressed on the surface of transfected cells at a rate several-fold higher than an analogously transfected H-2Ld molecule, we analyzed both previously described and new H-2 hybrid genes. These genes were constructed by exchanging domains between H-2 genes. Quantitative radioimmunoassay indicates that the region of the H-2Dd molecule responsible for its enhanced expression resides in the polymorphic N domain, the first domain of the mature class I molecule.
摘要
为了确定为何H-2Dd抗原在转染细胞表面的表达速率比类似转染的H-2Ld分子高几倍，我们分析了先前描述的和新的H-2杂交基因。这些基因是通过在H-2基因之间交换结构域构建的。定量放射免疫测定表明，H-2Dd分子中负责其增强表达的区域位于多态性N结构域，即成熟I类分子的第一个结构域。
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