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本文引用的文献

1
Quantitative variation in H-2-antigen expression. I. Estimation of H-2K and H-2D expression in different strains of mice.H-2抗原表达的定量变异。I. 不同品系小鼠中H-2K和H-2D表达的估计。
Immunogenetics. 1980;11(3):225-39. doi: 10.1007/BF01567790.
2
Monoclonal antibodies to mouse MHC antigens. II. Antibodies to the H-2Ld antigen, the products of a third polymorphic locus of the mouse major histocompatibility complex.针对小鼠MHC抗原的单克隆抗体。II. 针对H-2Ld抗原的抗体，小鼠主要组织相容性复合体第三个多态性位点的产物
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3
Hybridoma cell lines secreting monoclonal antibodies to mouse H-2 and Ia antigens.分泌针对小鼠H-2和Ia抗原的单克隆抗体的杂交瘤细胞系。
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4
Differential regulation of mouse H-2 alloantigens.小鼠H-2同种异体抗原的差异调节
Biochemistry. 1982 Nov 9;21(23):5730-8. doi: 10.1021/bi00266a001.
5
Identification of a BALB/c H-2Ld gene by DNA-mediated gene transfer.通过DNA介导的基因转移鉴定BALB/c H-2Ld基因。
Science. 1982 Feb 5;215(4533):677-9. doi: 10.1126/science.7058331.
6
Resistance to cell-mediated cytotoxicity is correlated with reduction of H-2K gene products in AKR leukemia.对细胞介导的细胞毒性的抗性与AKR白血病中H-2K基因产物的减少相关。
Immunogenetics. 1982;16(3):257-64. doi: 10.1007/BF00343314.
7
A pseudogene homologous to mouse transplantation antigens: transplantation antigens are encoded by eight exons that correlate with protein domains.一个与小鼠移植抗原同源的假基因：移植抗原由与蛋白质结构域相关的八个外显子编码。
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Identification of the class I genes of the mouse major histocompatibility complex by DNA-mediated gene transfer.通过DNA介导的基因转移鉴定小鼠主要组织相容性复合体的I类基因。
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9
Linkage and sequence homology of two human immunoglobulin gamma heavy chain constant region genes.两个人类免疫球蛋白γ重链恒定区基因的连锁与序列同源性
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10
Conversion of a secretory protein into a transmembrane protein results in its transport to the Golgi complex but not to the cell surface.分泌蛋白转化为跨膜蛋白会导致其被转运至高尔基体复合体，但不会被转运至细胞表面。
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H-2Dd和H-2Ld组织相容性抗原的差异表达。

Differential expression of H-2Dd and H-2Ld histocompatibility antigens.

作者信息

Weis J H, Murre C

出版信息

J Exp Med. 1985 Feb 1;161(2):356-65. doi: 10.1084/jem.161.2.356.

DOI:10.1084/jem.161.2.356
PMID:3919140
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2187564/
Abstract

To determine why the H-2Dd antigen is expressed on the surface of transfected cells at a rate several-fold higher than an analogously transfected H-2Ld molecule, we analyzed both previously described and new H-2 hybrid genes. These genes were constructed by exchanging domains between H-2 genes. Quantitative radioimmunoassay indicates that the region of the H-2Dd molecule responsible for its enhanced expression resides in the polymorphic N domain, the first domain of the mature class I molecule.

摘要

为了确定为何H-2Dd抗原在转染细胞表面的表达速率比类似转染的H-2Ld分子高几倍，我们分析了先前描述的和新的H-2杂交基因。这些基因是通过在H-2基因之间交换结构域构建的。定量放射免疫测定表明，H-2Dd分子中负责其增强表达的区域位于多态性N结构域，即成熟I类分子的第一个结构域。