两个人类免疫球蛋白γ重链恒定区基因的连锁与序列同源性
Linkage and sequence homology of two human immunoglobulin gamma heavy chain constant region genes.
作者信息
Ellison J, Hood L
出版信息
Proc Natl Acad Sci U S A. 1982 Mar;79(6):1984-8. doi: 10.1073/pnas.79.6.1984.
Abstract
We report the nucleotide sequence of a gene encoding a human immunoglobulin C gamma 2 region. Comparison with the previously determined C gamma 4 sequence reveals that these two genes share extensive (approximately 95%) homology in the three CH domain exons and adjacent noncoding regions. In contrast, hinge exons have diverged to a much greater degree, implying that natural selection has favored the generation of diversity in these coding regions. We have used the noncoding nucleotide differences to estimate that approximately 6-7 million years have elapsed since the occurrence of the gene duplication or correction event which generated the two identical ancestral genes. In addition we show that the two C gamma genes are arranged in human chromosomal DNA in the configuration 5'-C gamma 2-17 kilobase pairs -C gamma 4-3'.
摘要
我们报道了一个编码人免疫球蛋白Cγ2区基因的核苷酸序列。与先前确定的Cγ4序列比较显示，这两个基因在三个CH结构域外显子和相邻的非编码区具有广泛的（约95%）同源性。相比之下，铰链区外显子的差异程度要大得多，这意味着自然选择有利于这些编码区产生多样性。我们利用非编码核苷酸差异估计，自产生两个相同祖先基因的基因复制或校正事件发生以来，大约已经过去了600-700万年。此外，我们还表明，这两个Cγ基因在人类染色体DNA中的排列方式为5'-Cγ2-17千碱基对-Cγ4-3'。
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