Yu Wuyue, Thurston George, Shao Yongzhao, Zhang Yian, Copeland William E, Stein Cheryl R
Department of Medicine, NYU Grossman School of Medicine, New York, NY 10016, United States.
Department of Population Health, NYU Grossman School of Medicine, New York, NY 10016, United States.
Am J Epidemiol. 2025 Apr 8;194(4):975-983. doi: 10.1093/aje/kwae314.
Depression is a major contributor to the global burden of disease. There is limited understanding of how environmental exposures may contribute to depression etiology. We used wave 4 of the National Longitudinal Study of Adolescent to Adult Health (Add Health) to examine associations between low-level ambient air pollution exposure and depressed mood in a generally healthy population of over 10 000 24-32 year olds. Annual mean PM2.5 levels in the 2008-2009 study were close to the current US standard. In fully adjusted quasibinomial logistic regression models, there were no meaningful associations between IQR increases in air pollutant and change in depressed mood status regardless of specific pollutant or moving average lags. In interaction effects models, an IQR increase in lag day 0-30 PM2.5 resulted in 1.20 (95% CI, 1.02-1.41) times higher likelihood of having depressed mood but only for persons with chronic lung disease (interaction P = .04); the association was null for participants without chronic lung disease (OR, 0.98; 95% CI, 0.91-1.05). Our findings suggest that among persons with a lifetime history of chronic lung disease, greater exposure to even low-level PM2.5, PM10, and sulfate may be associated with modest increases in the likelihood of having depressed mood. This article is part of a Special Collection on Environmental Epidemiology.
抑郁症是全球疾病负担的主要促成因素。人们对环境暴露如何导致抑郁症病因的了解有限。我们利用青少年到成人健康的全国纵向研究（Add Health）的第四波数据，在超过10000名24 - 32岁的一般健康人群中，研究低水平环境空气污染暴露与抑郁情绪之间的关联。2008 - 2009年研究中的年平均PM2.5水平接近当前美国标准。在完全调整的拟二项逻辑回归模型中，无论特定污染物或移动平均滞后情况如何，空气污染物四分位间距增加与抑郁情绪状态变化之间均无显著关联。在交互效应模型中，滞后0 - 30天的PM2.5四分位间距增加会使抑郁情绪出现的可能性增加1.20倍（95%可信区间，1.02 - 1.41），但仅适用于患有慢性肺病的人群（交互P = 0.04）；对于没有慢性肺病的参与者，该关联不显著（比值比，0.98；95%可信区间，0.91 - 1.05）。我们的研究结果表明，在有慢性肺病终生病史的人群中，即使接触低水平的PM2.5、PM10和硫酸盐，也可能与抑郁情绪出现可能性的适度增加有关。本文是环境流行病学特刊的一部分。
