追求双侧肾母细胞瘤患儿的最佳治疗方法和强度。
Pursuit of the optimal therapeutic approach and intensity for children with bilateral Wilms tumour.
机构信息
Department of Surgery, St. Jude Children's Research Hospital, Memphis, TN, USA.
Division of Pediatric Surgery, Department of Surgery, University of Tennessee Health Science Center, Memphis, TN, USA.
出版信息
Br J Cancer. 2024 Oct;131(6):970-971. doi: 10.1038/s41416-024-02806-4. Epub 2024 Aug 27.
Abstract
Investigators from the International Society of Paediatric Oncology Renal Tumour Study Group (SIOP-RTSG) report on outcomes of children with bilateral Wilms tumour treated on the SIOP 2001 study. They demonstrate that vincristine and actinomycin-D induction chemotherapy is sufficient in a subset of children, but most required additional agents during their treatment.
摘要
国际小儿肿瘤学会肾脏肿瘤研究组（SIOP-RTSG）的研究人员报告了接受 SIOP 2001 研究方案治疗的双侧 Wilms 瘤患儿的结局。他们表明长春新碱和放线菌素-D 诱导化疗在一部分患儿中是足够的，但大多数患儿在治疗过程中需要额外的药物。
相似文献
1
Pursuit of the optimal therapeutic approach and intensity for children with bilateral Wilms tumour.追求双侧肾母细胞瘤患儿的最佳治疗方法和强度。
Br J Cancer. 2024 Oct;131(6):970-971. doi: 10.1038/s41416-024-02806-4. Epub 2024 Aug 27.
2
Outcome of patients with a first relapse after intermediate- or high-risk Wilms tumor, treated according to SIOP WT 2001/UK-IMPORT study; A report from the SIOP renal tumor study group.根据SIOP WT 2001/英国进口研究对中危或高危肾母细胞瘤首次复发患者进行治疗的结果；SIOP肾肿瘤研究组的报告
Urol Oncol. 2025 Sep;43(9):525.e19-525.e32. doi: 10.1016/j.urolonc.2025.05.018. Epub 2025 Jun 21.
3
Characteristics and outcome of synchronous bilateral Wilms tumour in the SIOP WT 2001 Study: Report from the SIOP Renal Tumour Study Group (SIOP-RTSG).SIOP WT 2001 研究中双侧同步 Wilms 肿瘤的特征和结局：SIOP 肾脏肿瘤研究组（SIOP-RTSG）的报告。
Br J Cancer. 2024 Oct;131(6):972-981. doi: 10.1038/s41416-024-02799-0. Epub 2024 Jul 30.
4
Response to letter commenting on "Outcome of localised blastemal-type Wilms tumour patients treated according to intensified treatment in the SIOP WT 2001 protocol, a report of the SIOP Renal Tumour Study Group (SIOP-RTSG)".对评论“国际小儿肿瘤学会（SIOP）肾肿瘤研究组（SIOP-RTSG）关于按照SIOP WT 2001方案强化治疗的局限性胚芽型威尔姆斯瘤患者的结局”的信件的回复
Eur J Cancer. 2015 May;51(8):995-6. doi: 10.1016/j.ejca.2015.03.006. Epub 2015 Mar 31.
5
Impact of neoadjuvant chemotherapy on tumour volume in unilateral Wilms tumour histotypes: a retrospective study.新辅助化疗对单侧肾母细胞瘤组织学类型肿瘤体积的影响：一项回顾性研究。
BMC Cancer. 2025 Jul 1;25(1):1031. doi: 10.1186/s12885-025-14177-x.
6
Omission of doxorubicin from the treatment of stage II-III, intermediate-risk Wilms' tumour (SIOP WT 2001): an open-label, non-inferiority, randomised controlled trial.从 II-III 期、中危 Wilms 瘤（SIOP WT 2001）的治疗中省略多柔比星：一项开放标签、非劣效性、随机对照试验。
Lancet. 2015 Sep 19;386(9999):1156-64. doi: 10.1016/S0140-6736(14)62395-3. Epub 2015 Jul 9.
7
Treatment including anthracyclines versus treatment not including anthracyclines for childhood cancer.用于儿童癌症治疗时，含蒽环类药物的治疗方案与不含蒽环类药物的治疗方案对比。
Cochrane Database Syst Rev. 2014 Sep 4;2014(9):CD006647. doi: 10.1002/14651858.CD006647.pub4.
8
Position paper: Rationale for the treatment of Wilms tumour in the UMBRELLA SIOP-RTSG 2016 protocol.立场文件：采用 SIOP-RTSG 2016 方案治疗肾母细胞瘤的理由。
Nat Rev Urol. 2017 Dec;14(12):743-752. doi: 10.1038/nrurol.2017.163. Epub 2017 Oct 31.
9
[Wilms' tumour of unfavorable histology--results of treatment with the SIOP 93-01 protocol at the Gdańsk centre. Preliminary report].[组织学不良的肾母细胞瘤——格但斯克中心采用SIOP 93-01方案的治疗结果。初步报告]
Med Wieku Rozwoj. 2004 Apr-Jun;8(2 Pt 1):197-200.
10
Optimal neoadjuvant chemotherapy duration in Wilms tumour with intravascular thrombus: A literature review and evidence from SIOP WT 2001 trial.血管内肿瘤栓子的 Wilms 瘤最佳新辅助化疗持续时间：文献复习及 SIOP WT 2001 试验证据。
Pediatr Blood Cancer. 2019 Nov;66(11):e27930. doi: 10.1002/pbc.27930. Epub 2019 Jul 24.
引用本文的文献
1
Bilateral Wilms Tumour: Is Neoadjuvant Doxorubicin Necessary?双侧肾母细胞瘤：新辅助阿霉素是否必要？
Children (Basel). 2025 Apr 30;12(5):587. doi: 10.3390/children12050587.
本文引用的文献
1
Characteristics and outcome of synchronous bilateral Wilms tumour in the SIOP WT 2001 Study: Report from the SIOP Renal Tumour Study Group (SIOP-RTSG).SIOP WT 2001 研究中双侧同步 Wilms 肿瘤的特征和结局：SIOP 肾脏肿瘤研究组（SIOP-RTSG）的报告。
Br J Cancer. 2024 Oct;131(6):972-981. doi: 10.1038/s41416-024-02799-0. Epub 2024 Jul 30.
2
Long-term outcomes and patterns of relapse in patients with bilateral Wilms tumor or bilaterally predisposed unilateral Wilms tumor, a report from the COG AREN0534 study.COG AREN0534 研究报告：双侧 Wilms 肿瘤或双侧倾向单侧 Wilms 肿瘤患者的长期结果和复发模式。
Int J Cancer. 2024 Nov 15;155(10):1824-1831. doi: 10.1002/ijc.35080. Epub 2024 Jul 8.
3
Genetic and epigenetic features of bilateral Wilms tumor predisposition in patients from the Children's Oncology Group AREN18B5-Q.双侧 Wilms 肿瘤易感患者的遗传和表观遗传特征：来自儿童肿瘤协作组 AREN18B5-Q 的研究。
Nat Commun. 2023 Dec 18;14(1):8006. doi: 10.1038/s41467-023-43730-0.
4
The pathophysiology of bilateral and multifocal Wilms tumors: What we can learn from the study of predisposition syndromes.双侧和多灶性肾母细胞瘤的病理生理学：从易感性综合征研究中学到的知识。
Pediatr Blood Cancer. 2023 May;70 Suppl 2:e29984. doi: 10.1002/pbc.29984. Epub 2022 Sep 12.
5
Circulating Tumor DNA as a Biomarker in Patients With Stage III and IV Wilms Tumor: Analysis From a Children's Oncology Group Trial, AREN0533.循环肿瘤 DNA 作为 III 期和 IV 期肾母细胞瘤患者的生物标志物：来自儿童肿瘤学组试验的分析，AREN0533。
J Clin Oncol. 2022 Sep 10;40(26):3047-3056. doi: 10.1200/JCO.22.00098. Epub 2022 May 17.
6
Embryonal precursors of Wilms tumor.Wilms 瘤的胚胎前体。
Science. 2019 Dec 6;366(6470):1247-1251. doi: 10.1126/science.aax1323.
7
Results of the First Prospective Multi-institutional Treatment Study in Children With Bilateral Wilms Tumor (AREN0534): A Report From the Children's Oncology Group.双侧肾母细胞瘤患儿的首个前瞻性多机构治疗研究（AREN0534）结果：来自儿童肿瘤协作组的报告
Ann Surg. 2017 Sep;266(3):470-478. doi: 10.1097/SLA.0000000000002356.
8
Bilateral Wilms tumour: a review of clinical and molecular features.双侧肾母细胞瘤：临床与分子特征综述
Expert Rev Mol Med. 2017 Jul 18;19:e8. doi: 10.1017/erm.2017.8.
9
Advances in Wilms Tumor Treatment and Biology: Progress Through International Collaboration.肾母细胞瘤治疗与生物学进展：通过国际合作取得的成果
J Clin Oncol. 2015 Sep 20;33(27):2999-3007. doi: 10.1200/JCO.2015.62.1888. Epub 2015 Aug 24.
10
End stage renal disease in patients with Wilms tumor: results from the National Wilms Tumor Study Group and the United States Renal Data System.肾母细胞瘤患者的终末期肾病：来自国家肾母细胞瘤研究组和美国肾脏数据系统的结果。
J Urol. 2005 Nov;174(5):1972-5. doi: 10.1097/01.ju.0000176800.00994.3a.
Zotero 插件