[Behavior of the concentration of triiodothyronine, thyroxine, thyrotropin and thyroxine-binding globulin in the serum of children with nephrotic syndrome].

Concentrations of triiodothyronine, thyroxine, thyrotropin, thyroxine-binding globulin, urea, creatinine, cholesterol and total protein were determined in serum of six children (ages from 4 to 16 years) with nephrotic syndrome undergoing therapy. The results showed that with decreasing concentration of serum protein and increasing concentration of cholesterol the concentrations of thyroxine and thyroxine-binding globulin decreased whereas the concentration of thyrotropin was elevated. Improvement in the concentration of serum protein lead to an improvement of serum levels of thyroid hormones and thyroxine-binding globulin; concentrations of thyrotropin and cholesterol returned to values close to normal. Although triiodothyronine was decreased slightly it remained in the normal range thus preventing overt hypothyroidism.