鉴定病毒基因/蛋白逃避抗病毒先天免疫的指南策略。
A Guideline Strategy for Identifying a Viral Gene/Protein Evading Antiviral Innate Immunity.
机构信息
Jiangsu Key Laboratory of Immunity and Metabolism, Department of Pathogenic Biology and Immunology, Xuzhou Medical University, Xuzhou, Jiangsu, China.
Department of Microbiology, Immunology and Infectious Diseases, University of Calgary, Calgary, AB, Canada.
出版信息
Methods Mol Biol. 2025;2854:9-18. doi: 10.1007/978-1-0716-4108-8_2.
Antiviral innate immunity is the first line of defence against viruses. The interferon (IFN) signaling pathway, the DNA damage response (DDR), apoptosis, endoplasmic reticulum (ER) stress, and autophagy are involved in antiviral innate immunity. Viruses abrogate the antiviral immune response of cells to replication in various ways. Viral genes/proteins play a key role in evading antiviral innate immunity. Here, we will discuss the interference of viruses with antiviral innate immunity and the strategy for identifying viral gene/protein immune evasion.
抗病毒先天免疫是抵御病毒的第一道防线。干扰素 (IFN) 信号通路、DNA 损伤反应 (DDR)、细胞凋亡、内质网 (ER) 应激和自噬都参与了抗病毒先天免疫。病毒通过多种方式破坏细胞的抗病毒免疫反应以进行复制。病毒基因/蛋白在逃避抗病毒先天免疫中起着关键作用。在这里，我们将讨论病毒对抗病毒先天免疫的干扰以及鉴定病毒基因/蛋白免疫逃避的策略。
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