Department of Obstetrics and Gynecology, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong Province, 510630, China.
Department of Obstetrics and Gynecology, Dongguan Eastern Central Hospital, The Sixth Affiliated Hospital of Jinan University, Dongguan, Guangdong Province, 523576, China.
BMC Endocr Disord. 2024 Aug 27;24(1):159. doi: 10.1186/s12902-024-01693-3.
The present study aimed to investigate the relationship between mean platelet volume (MPV) and the risk of type 2 diabetes mellitus (T2DM), among women with and without a history of gestational diabetes mellitus (GDM).
Eight thousand one hundred eighty-one parous women of the '2007-2018 National Health and Nutrition Examination Survey (NHANES)' were classified into GDM and non-GDM groups based on self-reported GDM history. We investigated the independent association between the MPV and the risk of T2DM in these groups via multivariable regression analysis. A subgroup analysis was done for the GDM group.
After comprehensive adjustment for potential covariates, a significant positive correlation was observed between MPV and the risk of T2DM in women with a history of GDM (OR = 1.50, 95% CI 1.13-2.01, P = 0.006). There was a linear relationship between MPV and T2DM among women with a history of GDM, with each unit increase in MPV increasing the risk of T2DM by 50%. Subgroup analysis and interaction tests revealed a stronger significant effect on women with GDM history who had HbA1c ≥ 7%.
MPV is strongly associated with the incidence of T2DM among U.S. parous women with prior GDM, indicating that MPV may be a potential biomarker of T2DM among women with a history of GDM.
本研究旨在探讨血小板平均体积（MPV）与 2 型糖尿病（T2DM）风险之间的关系，包括有和无妊娠糖尿病（GDM）病史的女性。
根据自我报告的 GDM 病史，将“2007-2018 年全国健康和营养调查（NHANES）”中的 8181 名经产妇女分为 GDM 和非 GDM 组。我们通过多变量回归分析调查了这些组中 MPV 与 T2DM 风险之间的独立关联。对 GDM 组进行了亚组分析。
在综合调整了潜在混杂因素后，在有 GDM 病史的女性中，MPV 与 T2DM 风险呈显著正相关（OR=1.50，95%CI 1.13-2.01，P=0.006）。在有 GDM 病史的女性中，MPV 与 T2DM 之间存在线性关系，MPV 每增加一个单位，T2DM 的风险就会增加 50%。亚组分析和交互检验显示，对于 HbA1c≥7%的有 GDM 病史的女性，这种显著影响更强。
MPV 与美国有 GDM 病史的经产妇女中 T2DM 的发生率密切相关，这表明 MPV 可能是 GDM 病史女性中 T2DM 的一个潜在生物标志物。
