平均血小板体积在预测早孕期妊娠期糖尿病中的作用。
Role of mean platelet volume in pregnancy to predict gestational diabetes mellitus in the first trimester.
机构信息
Department of Obstetrics and Gynecology, Medical Faculty, Baskent University, Konya, Turkey.
Department of Obstetrics and Gynecology, Medical Faculty, Baskent University, Ankara, Turkey.
出版信息
J Matern Fetal Neonatal Med. 2020 Nov;33(21):3689-3694. doi: 10.1080/14767058.2019.1583730. Epub 2019 Apr 4.
Gestational diabetes mellitus (GDM) is defined as glucose intolerance detected for the first time in pregnancy or identified during pregnancy. Mean platelet volume (MPV) is a marker of activation and function of platelet. Several studies investigated the relation between MPV and GDM. The purpose of the present study is to predict GDM in the first trimester by using MPV value. Two hundred pregnant women with GDM and 200 normal pregnant women were enrolled in the study. The first trimester MPV values of GDM and control groups were compared to predict GDM in the first trimester. Women with GDM had higher MPV value compared with the control group ( < .001). The area under the receiver-operator curve was 0.70 for MPV. The cutoff value of MPV was 7.38 fl with 70% sensitivity and 60% specificity. According to the ages, MPV value was higher in GDM group in the individuals who were above 28-year-old ( < .001). MPV can be used to predict GDM in the first trimester.
妊娠期糖尿病（GDM）定义为在妊娠期间首次发现或诊断的葡萄糖不耐受。平均血小板体积（MPV）是血小板活化和功能的标志物。一些研究探讨了 MPV 与 GDM 之间的关系。本研究旨在通过使用 MPV 值来预测早孕期 GDM。本研究纳入了 200 例 GDM 孕妇和 200 例正常孕妇。比较 GDM 和对照组早孕期 MPV 值，以预测早孕期 GDM。与对照组相比，GDM 组的 MPV 值更高（<0.001）。MPV 的受试者工作特征曲线下面积为 0.70。MPV 的截断值为 7.38fl，灵敏度为 70%，特异性为 60%。根据年龄，在年龄大于 28 岁的 GDM 组中，MPV 值更高（<0.001）。MPV 可用于预测早孕期 GDM。
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