[胶原肽对模拟微重力下小鼠T淋巴细胞功能的影响]
[Effect of Collagen Peptides on Function of Mouse T Lymphocytes under Simulated Microgravity].
作者信息
Si Shao-Yan, Qin Ya-Ya, Wu Ying-Ying, Ma Xiao-Yu, Shang Ying, Song Shu-Jun, Guo Yan-Chuan
机构信息
Department of Comprehensive Basic Experiment (Division Two), Strategic Support Force Medical Center, Beijing 100101, China.
Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Beijing 100190, China.
出版信息
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2024 Aug;32(4):1258-1263. doi: 10.19746/j.cnki.issn.1009-2137.2024.04.043.
OBJECTIVE
To understand the effect of collagen peptides on the function of mouse lymphocytes under simulated microgravity.
METHODS
The splenocytes of mice were isolated, and the rotary cell culture system was used to simulate the microgravity. The T lymphocytes were stimulated with mitotic agents, concanavalin A (ConA), and the cells were treated with different concentrations of collagen peptides. The proliferation of lymphocytes and the levels of cytokines in the supernatant were detected.
RESULTS
Simulated microgravity could inhibit the proliferation of spleen T lymphocytes and decrease the level of cytokines in the supernatant. Collagen peptides could promote the lymphocyte proliferation and cytokine production in cells cultured under simulated microgravity.
CONCLUSION
Collagen peptides may attenuate the inhibitory effect of simulated microgravity on T lymphocytes by regulating the cell proliferation and the secretion of cytokines.
目的
了解胶原蛋白肽对模拟微重力条件下小鼠淋巴细胞功能的影响。
方法
分离小鼠脾细胞，采用旋转细胞培养系统模拟微重力。用有丝分裂原刀豆蛋白A（ConA）刺激T淋巴细胞，并用不同浓度的胶原蛋白肽处理细胞。检测淋巴细胞的增殖情况及上清液中细胞因子的水平。
结果
模拟微重力可抑制脾T淋巴细胞的增殖并降低上清液中细胞因子的水平。胶原蛋白肽可促进模拟微重力条件下培养的细胞中淋巴细胞的增殖及细胞因子的产生。
结论
胶原蛋白肽可能通过调节细胞增殖和细胞因子分泌来减轻模拟微重力对T淋巴细胞的抑制作用。
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