Liu Qi, Shen Wen-Qing
Key Laboratory of Physiological and Biochemical Testing and Exercise Rehabilitation, School of Physical Education, Anhui Normal University, Wuhu 241002, China.
Sheng Li Xue Bao. 2024 Aug 25;76(4):576-586.
Cysteine dioxygenase type 1 (CDO1) belongs to the cysteine dioxygenase (CDO) family. CDO1 is the key enzyme in cysteine catabolism and taurine synthesis. CDO1 is highly expressed in liver, adipose tissue, pancreas, kidney, lung, brain and small intestine. CDO1 is involved in the pathophysiological regulation of various common metabolic diseases, such as lipid metabolism disorders, insulin resistance, obesity, tumors/cancers, and neurodegenerative diseases. This article summarizes the research progress on the molecular mechanisms of CDO1 regulation of common metabolic diseases in recent years, aiming to provide new theoretical and practical basis for CDO1-targeted therapy for insulin resistance, obesity, tumors/cancers, and neurodegenerative diseases.
1型半胱氨酸双加氧酶（CDO1）属于半胱氨酸双加氧酶（CDO）家族。CDO1是半胱氨酸分解代谢和牛磺酸合成中的关键酶。CDO1在肝脏、脂肪组织、胰腺、肾脏、肺、脑和小肠中高表达。CDO1参与多种常见代谢性疾病的病理生理调节，如脂质代谢紊乱、胰岛素抵抗、肥胖、肿瘤/癌症和神经退行性疾病。本文综述了近年来CDO1调控常见代谢性疾病分子机制的研究进展，旨在为针对胰岛素抵抗、肥胖、肿瘤/癌症和神经退行性疾病的CDO1靶向治疗提供新的理论和实践依据。
