通过中药调节肠道微生物群治疗糖尿病周围神经病变的研究进展
Advances in the treatment of diabetic peripheral neuropathy by modulating gut microbiota with traditional Chinese medicine.
作者信息
Li Ye-Yao, Guan Rui-Qian, Hong Zhi-Bo, Wang Yao-Lei, Pan Li-Min
机构信息
Department of Endocrinology, The Second Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin 150001, Heilongjiang Province, China.
Department of Tuina, The Second Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin 150001, Heilongjiang Province, China.
出版信息
World J Diabetes. 2024 Aug 15;15(8):1712-1716. doi: 10.4239/wjd.v15.i8.1712.
Abstract
Diabetic peripheral neuropathy (DPN) is one of the strongest risk factors for diabetic foot ulcers (neuropathic ulcerations) and the existing ulcers may further deteriorate due to the damage to sensory neurons. Moreover, the resulting numbness in the limbs causes difficulty in discovering these ulcerations in a short time. DPN is associated with gut microbiota dysbiosis. Traditional Chinese medicine (TCM) compounds such as Shenqi Dihuang Decoction, Huangkui Capsules and Qidi Tangshen Granules can reduce the clinical symptoms of diabetic nephropathy by modulating gut microbiota. The current review discusses whether TCM compounds can reduce the risk of DPN by improving gut mic-robiota.
摘要
糖尿病周围神经病变（DPN）是糖尿病足溃疡（神经性溃疡）最强的危险因素之一，并且由于感觉神经元受损，现有的溃疡可能会进一步恶化。此外，由此导致的肢体麻木使得在短时间内发现这些溃疡变得困难。DPN与肠道微生物群失调有关。诸如肾气地黄汤、黄葵胶囊和芪地糖肾颗粒等中药复方可以通过调节肠道微生物群来减轻糖尿病肾病的临床症状。本综述讨论了中药复方是否可以通过改善肠道微生物群来降低DPN的风险。
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