释放甲醛的抗肿瘤药物六甲蜜胺对沙门氏菌的弱致突变性。

Weak mutagenicity to Salmonella of the formaldehyde-releasing anti-tumour agent hexamethylmelamine.

作者信息

Ashby J, Callander R D, Rose F L

出版信息

Mutat Res. 1985 Mar;142(3):121-5. doi: 10.1016/0165-7992(85)90051-x.

PMID:3919288

Abstract

Hexamethylmelamine (HEMLA) is a metabolism-dependent formaldehyde-releasing agent related in structure to hexamethylphosphoramide (HMPA). Both compounds are known to be mutagenic to Drosophila. HMPA, in common with the other formaldehyde-releasing agents studied, is non-mutagenic to Salmonella. The present paper describes the mutagenicity of HEMLA to strain TA100 of Salmonella typhimurium. Activity is dependent upon both the use of a pre-incubation assay protocol and on high concentrations of Aroclor-induced rat liver in the S9 mix. HMPA was inactive under similar conditions of test.

摘要

六甲蜜胺（HEMLA）是一种与六甲磷酰胺（HMPA）结构相关的依赖代谢的甲醛释放剂。已知这两种化合物对果蝇具有致突变性。与所研究的其他甲醛释放剂一样，HMPA对沙门氏菌无致突变性。本文描述了HEMLA对鼠伤寒沙门氏菌TA100菌株的致突变性。活性既取决于预孵育试验方案的使用，也取决于S9混合物中高浓度的艾氏剂诱导的大鼠肝脏。在类似的试验条件下，HMPA无活性。