Chen Rongrong, Wang Rui, Yu Yanmei, Zhao Kun, Li Juebao
Center for Rehabilitation Medicine, Rehabilitation and Sports Medicine Research Institute of Zhejiang Province, Department of Rehabilitation Medicine, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China.
School of Basic Medical Sciences, Zhejiang University School of Medicine, Hangzhou, China.
Front Neurol. 2024 Aug 13;15:1378494. doi: 10.3389/fneur.2024.1378494. eCollection 2024.
Intravaginal electrical stimulation (IVES) has been explored as a potential treatment for pelvic floor disorders (PFDs), although its efficacy remains a subject of debate. We aim to conducted a comprehensive meta-analysis of relevant trials.
This meta-analysis was performed under the PRISMA 2020 guideline. We meticulously searched for randomized controlled trial (RCT) studies in various databases, including PubMed, Cochrane Library, EMBASE, and ClinicalTrials.gov, spanning from inception to March 6, 2023. All studies included one treatment group of intravaginal electrical stimulation and the diseases spectrum of the studies involved different kinds of PFDs, including urinary incontinence, overactive bladder, etc. Risk of bias charts were used to assess the risk of bias in the studies and forest plots were used the demonstrate the overall effects.
Our analysis encompassed a total of 13 RCT studies. In most of the assessed PFD cure outcomes, the results demonstrated positive effects of IVES therapy, as indicated by the following findings: daily voiding frequency (MD = -1.57, 95% CI = -3.08 to -0.06, = 68%,), nocturia (MD = -1.07, 95% CI = -2.01 to -0.13, = 71%), Pad test, and Urinary incontinence. Nevertheless, the data concerning the impact of IVES therapy on the quality of life of individuals with PFDs did not confirm these positive results.
In light of the insufficiency in both the quality and quantity of the included studies, it is premature to draw a definitive conclusion regarding the efficacy of IVES therapy for treating PFDs. Nonetheless, our study does provide several pieces of evidence in support of the potential therapeutic effects of electrical stimulation therapy in this context. We recommend that further research in this area be conducted to provide more conclusive insights into the efficacy of IVES therapy for PFDs.
https://www.crd.york.ac.uk/prospero/, identifier: CRD42023442171.
阴道内电刺激（IVES）已被探索作为盆底功能障碍（PFDs）的一种潜在治疗方法，尽管其疗效仍存在争议。我们旨在对相关试验进行全面的荟萃分析。
本荟萃分析按照PRISMA 2020指南进行。我们在包括PubMed、Cochrane图书馆、EMBASE和ClinicalTrials.gov在内的多个数据库中精心搜索了从开始到2023年3月6日的随机对照试验（RCT）研究。所有研究包括一个阴道内电刺激治疗组，且研究涉及的疾病谱包括不同类型的PFDs，如尿失禁、膀胱过度活动症等。使用偏倚风险图评估研究中的偏倚风险，并使用森林图展示总体效果。
我们的分析共纳入了13项RCT研究。在大多数评估的PFD治愈结果中，结果显示IVES治疗有积极效果，如下所示：每日排尿频率（MD = -1.57，95%CI = -3.08至-0.06，I² = 68%）、夜尿症（MD = -1.07，95%CI = -2.01至-0.13，I² = 71%）、护垫试验和尿失禁。然而，关于IVES治疗对PFD患者生活质量影响的数据并未证实这些积极结果。
鉴于纳入研究在质量和数量上的不足，就IVES治疗PFDs的疗效得出明确结论还为时过早。尽管如此，我们的研究确实提供了一些证据支持电刺激疗法在这种情况下的潜在治疗效果。我们建议在该领域进行进一步研究，以更确凿地了解IVES治疗PFDs的疗效。
