• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

合成阳离子通道：在人工系统中重建TRPA1的离子渗透途径。

Synthetic cation channel: reconstructing the ion permeation pathway of TRPA1 in an artificial system.

作者信息

Xin Pengyang, Ren Wenke, Zhu Qiuhui, Wang Jie, Sun Yonghui, Chang Junbiao, Zhu Gongming

机构信息

State Key Laboratory of Antiviral Drugs, Pingyuan Laboratory, NMPA Key Laboratory for Research and Evaluation of Innovative Drug, School of Chemistry and Chemical Engineering, Henan Normal University Xinxiang 453007 China

出版信息

RSC Adv. 2024 Aug 27;14(37):26933-26937. doi: 10.1039/d4ra05676k. eCollection 2024 Aug 22.

DOI:10.1039/d4ra05676k
PMID:39193288
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11348841/
Abstract

A novel artificial cation channel was developed by rebuilding the ion permeation pathway of the natural channel protein (TRPA1) in a synthetic system. This tubular molecule can effectively embed into lipid bilayers and form transmembrane channels, thereby mediating cation transport. Furthermore, due to its carboxyl-modified ion permeation pathway, the transport activity of this artificial channel can be modulated by the pH of the buffer solution.

摘要

通过在合成系统中重建天然通道蛋白（TRPA1）的离子渗透途径，开发了一种新型人工阳离子通道。这种管状分子能够有效地嵌入脂质双层并形成跨膜通道，从而介导阳离子运输。此外，由于其离子渗透途径经过羧基修饰，该人工通道的运输活性可被缓冲溶液的pH值调节。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/375e/11348841/fd429412fb70/d4ra05676k-f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/375e/11348841/ac51617a6bc7/d4ra05676k-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/375e/11348841/13262c31e21f/d4ra05676k-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/375e/11348841/4c0e1e3f4221/d4ra05676k-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/375e/11348841/624bb4a97b11/d4ra05676k-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/375e/11348841/886f360e8944/d4ra05676k-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/375e/11348841/20ef27d7cd8f/d4ra05676k-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/375e/11348841/a4afaae7df41/d4ra05676k-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/375e/11348841/fd429412fb70/d4ra05676k-f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/375e/11348841/ac51617a6bc7/d4ra05676k-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/375e/11348841/13262c31e21f/d4ra05676k-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/375e/11348841/4c0e1e3f4221/d4ra05676k-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/375e/11348841/624bb4a97b11/d4ra05676k-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/375e/11348841/886f360e8944/d4ra05676k-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/375e/11348841/20ef27d7cd8f/d4ra05676k-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/375e/11348841/a4afaae7df41/d4ra05676k-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/375e/11348841/fd429412fb70/d4ra05676k-f8.jpg

相似文献

1
Synthetic cation channel: reconstructing the ion permeation pathway of TRPA1 in an artificial system.合成阳离子通道：在人工系统中重建TRPA1的离子渗透途径。
RSC Adv. 2024 Aug 27;14(37):26933-26937. doi: 10.1039/d4ra05676k. eCollection 2024 Aug 22.
2
Redox-Regulated Synthetic Channels: Enabling Reversible Ion Transport by Modulating the Ion-Permeation Pathway.氧化还原调控的合成通道：通过调节离子渗透通道实现离子的可逆输运
Angew Chem Int Ed Engl. 2024 May 13;63(20):e202403667. doi: 10.1002/anie.202403667. Epub 2024 Mar 15.
3
Agonist-induced changes in Ca(2+) permeation through the nociceptor cation channel TRPA1.激动剂诱导伤害感受性阳离子通道 TRPA1 钙渗透的变化。
Biophys J. 2010 Mar 3;98(5):773-83. doi: 10.1016/j.bpj.2009.11.007.
4
Synthetic K Channels Constructed by Rebuilding the Core Modules of Natural K Channels in an Artificial System.通过在人工系统中重建天然钾通道的核心模块构建的合成钾通道。
Angew Chem Int Ed Engl. 2023 Feb 13;62(8):e202217859. doi: 10.1002/anie.202217859. Epub 2023 Jan 18.
5
Mutations in the voltage-sensing domain affect the alternative ion permeation pathway in the TRPM3 channel.电压感应域中的突变会影响 TRPM3 通道中的替代离子渗透途径。
J Physiol. 2018 Jun;596(12):2413-2432. doi: 10.1113/JP274124. Epub 2018 Apr 25.
6
Human TRPA1 is an inherently mechanosensitive bilayer-gated ion channel.人源瞬时受体电位通道 A1（TRPA1）是一种固有机械敏感性双分子层门控离子通道。
Cell Calcium. 2020 Nov;91:102255. doi: 10.1016/j.ceca.2020.102255. Epub 2020 Jul 18.
7
Pore dilation occurs in TRPA1 but not in TRPM8 channels.TRPA1通道会出现孔扩张现象，而TRPM8通道则不会。
Mol Pain. 2009 Jan 21;5:3. doi: 10.1186/1744-8069-5-3.
8
Flexible Single-Chain-Heteropolymer-Derived Transmembrane Ion Channels with High K Selectivity and Tunable pH-Gated Characteristics.具有高钾选择性和可调 pH 门控特性的柔性单链杂多酸衍生的跨膜离子通道。
Angew Chem Int Ed Engl. 2022 Oct 17;61(42):e202210214. doi: 10.1002/anie.202210214. Epub 2022 Sep 12.
9
Synthesis and characterization of a redox-active ion channel supporting cation flux in lipid bilayers.一种支持脂质双分子层中阳离子通量的氧化还原活性离子通道的合成与表征。
Org Biomol Chem. 2009 Sep 21;7(18):3862-70. doi: 10.1039/b907350g. Epub 2009 Jul 22.
10
Comparing ion conductance recordings of synthetic lipid bilayers with cell membranes containing TRP channels.比较合成脂质双分子层与含有瞬时受体电位（TRP）通道的细胞膜的离子电导记录。
Biochim Biophys Acta. 2012 May;1818(5):1123-34. doi: 10.1016/j.bbamem.2012.01.014. Epub 2012 Jan 28.

本文引用的文献

1
Constructing artificial gap junctions to mediate intercellular signal and mass transport.构建人工缝隙连接以介导细胞间信号和物质转运。
Nat Chem. 2024 Sep;16(9):1418-1426. doi: 10.1038/s41557-024-01519-8. Epub 2024 Apr 24.
2
Efficient Sodium Transmembrane Permeation through Helically Folded Nanopores with Natural Channel-Like Ion Selectivity.通过具有天然通道样离子选择性的螺旋折叠纳米孔实现高效的钠跨膜渗透。
J Am Chem Soc. 2024 Mar 27;146(12):8500-8507. doi: 10.1021/jacs.3c14736. Epub 2024 Mar 14.
3
Concentration-Driven Evolution of Adaptive Artificial Ion Channels or Nanopores with Specific Anticancer Activities.
具有特定抗癌活性的适应性人工离子通道或纳米孔的浓度驱动进化。
Angew Chem Int Ed Engl. 2024 Apr 22;63(17):e202318811. doi: 10.1002/anie.202318811. Epub 2024 Mar 18.
4
Redox-Regulated Synthetic Channels: Enabling Reversible Ion Transport by Modulating the Ion-Permeation Pathway.氧化还原调控的合成通道：通过调节离子渗透通道实现离子的可逆输运
Angew Chem Int Ed Engl. 2024 May 13;63(20):e202403667. doi: 10.1002/anie.202403667. Epub 2024 Mar 15.
5
Molecular Motor-Driven Light-Controlled Logic-Gated K Channel for Cancer Cell Apoptosis.分子马达驱动的光控逻辑门 K 通道用于癌细胞凋亡。
Adv Mater. 2024 May;36(19):e2312352. doi: 10.1002/adma.202312352. Epub 2024 Feb 11.
6
Reversing the ion transport selectivity through arm modification of an artificial molecular hourglass.通过对人工分子沙漏进行臂修饰来逆转离子传输选择性。
Chem Commun (Camb). 2023 Dec 12;59(99):14689-14692. doi: 10.1039/d3cc04573k.
7
Aromatic pentaamide macrocycles bind anions with high affinity for transport across biomembranes.芳基五酰胺大环配合物以高亲和力结合阴离子，有利于穿过生物膜进行运输。
Nat Chem. 2023 Nov;15(11):1559-1568. doi: 10.1038/s41557-023-01315-w. Epub 2023 Oct 9.
8
Selective Water Pore Recognition and Transport through Self-Assembled Alkyl-Ureido-Trianglamine Artificial Water Channels.通过自组装烷基-脲基-三胺人工水通道实现选择性水孔识别与运输。
J Am Chem Soc. 2023 Oct 4;145(39):21213-21221. doi: 10.1021/jacs.3c02815. Epub 2023 Sep 26.
9
A Benzohydrazide-Based Artificial Ion Channel that Modulates Chloride Ion Concentration in Cancer Cells and Induces Apoptosis by Disruption of Autophagy.一种苯甲酰肼基人工离子通道，通过破坏自噬来调节癌细胞中的氯离子浓度并诱导细胞凋亡。
J Am Chem Soc. 2023 May 3;145(17):9737-9745. doi: 10.1021/jacs.3c01451. Epub 2023 Apr 6.
10
An Artificial Single Molecular Channel Showing High Chloride Transport Selectivity and pH-Responsive Conductance.一种具有高氯离子传输选择性和 pH 响应电导的人工单分子通道。
Angew Chem Int Ed Engl. 2023 Jun 5;62(23):e202302198. doi: 10.1002/anie.202302198. Epub 2023 May 3.