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安罗替尼通过抑制活化的癌相关成纤维细胞中的细胞因子分泌来抑制宫颈癌细胞的增殖和侵袭。

Anlotinib inhibits cervical cancer cell proliferation and invasion by suppressing cytokine secretion in activated cancer-associated fibroblasts.

作者信息

Xiong Yaozu, Xu Xiaoting, Zhou Xilei, Tong Yusuo, Yu Changhua

机构信息

Department of Radiation Oncology, Huai'an First People's Hospital, Nanjing Medical University, Huai'an, China.

Department of Radiation Oncology, The First Affiliated Hospital of Soochow University, Suzhou, China.

出版信息

Front Oncol. 2024 Aug 13;14:1412660. doi: 10.3389/fonc.2024.1412660. eCollection 2024.

DOI:10.3389/fonc.2024.1412660
PMID:39193386
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11347301/
Abstract

OBJECTIVE

The aim of this study was to investigate whether anlotinib could exert an inhibitory effect on the proliferation and invasion of cervical cancer cells by inhibiting cytokines secreted by activated cancer-associated fibroblasts (CAFs).

METHODS

CAFs were isolated from cervical cancer tissues and experimentally studied and . Molecular biology experimental methods were used to verify whether anlotinib could inhibit the pro-carcinogenic effects of CAFs derived from cervical cancer tissues.

RESULTS

CAFs promote the proliferation and invasion of cervical cancer cells. Anlotinib inhibited the activation of CAFs and suppressed the promotion of cervical cancer cells by CAFs. Anlotinib inhibited the expression of multiple cytokines within CAFs and suppressed the release of interleukin (IL)-6 (IL-6) and IL-8. studies have shown that anlotinib diminished the growth of xenografted cervical cancer cells, and treatment in combination with docetaxel had an even more significant tumor growth inhibitory effect.

CONCLUSION

Anlotinib inhibits the pro-cancer effects of CAFs by suppressing the activation of CAFs and the secretion of pro-cancer cytokines. Our findings suggest that the combination of anlotinib and docetaxel may be a potential strategy for the treatment of refractory cervical cancer.

摘要

目的

本研究旨在探讨安罗替尼是否可通过抑制活化的癌相关成纤维细胞（CAFs）分泌的细胞因子，对宫颈癌细胞的增殖和侵袭发挥抑制作用。

方法

从宫颈癌组织中分离出CAFs并进行实验研究。采用分子生物学实验方法验证安罗替尼是否能抑制源自宫颈癌组织的CAFs的促癌作用。

结果

CAFs促进宫颈癌细胞的增殖和侵袭。安罗替尼抑制CAFs的活化，并抑制CAFs对宫颈癌细胞的促进作用。安罗替尼抑制CAFs内多种细胞因子的表达，并抑制白细胞介素（IL）-6和IL-8的释放。研究表明，安罗替尼可减少异种移植宫颈癌细胞的生长，与多西他赛联合治疗对肿瘤生长的抑制作用更为显著。

结论

安罗替尼通过抑制CAFs的活化和促癌细胞因子的分泌来抑制CAFs的促癌作用。我们的研究结果表明，安罗替尼与多西他赛联合使用可能是治疗难治性宫颈癌的一种潜在策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29c0/11347301/20c7678741c3/fonc-14-1412660-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29c0/11347301/056084c6800c/fonc-14-1412660-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29c0/11347301/9ad36d53b0fe/fonc-14-1412660-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29c0/11347301/815aebb0b9c3/fonc-14-1412660-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29c0/11347301/73bc7d23eabe/fonc-14-1412660-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29c0/11347301/75395017cc21/fonc-14-1412660-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29c0/11347301/d44862dc7cc0/fonc-14-1412660-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29c0/11347301/a9e7bc5a66da/fonc-14-1412660-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29c0/11347301/20c7678741c3/fonc-14-1412660-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29c0/11347301/056084c6800c/fonc-14-1412660-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29c0/11347301/9ad36d53b0fe/fonc-14-1412660-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29c0/11347301/815aebb0b9c3/fonc-14-1412660-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29c0/11347301/73bc7d23eabe/fonc-14-1412660-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29c0/11347301/75395017cc21/fonc-14-1412660-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29c0/11347301/d44862dc7cc0/fonc-14-1412660-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29c0/11347301/a9e7bc5a66da/fonc-14-1412660-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29c0/11347301/20c7678741c3/fonc-14-1412660-g008.jpg

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Pulm Pharmacol Ther. 2023 Jun;80:102202. doi: 10.1016/j.pupt.2023.102202. Epub 2023 Mar 10.
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