Department of Critical Care Medicine, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China.
Department of Critical Care Medicine, West China Tianfu Hospital of Sichuan University, Chengdu 610200, Sichuan Province, China.
World J Gastroenterol. 2024 Aug 14;30(30):3609-3624. doi: 10.3748/wjg.v30.i30.3609.
Sepsis-associated liver injury (SLI) is a severe and prevalent complication of sepsis.
To explore the literature on SLI a bibliometric approach.
Reviews and articles correlated with SLI published from January 1, 2000 to October 28, 2023 were searched from the Web of Science Core Collection. Then, the searched data were analyzed using VOSviewer, CiteSpace, and R language.
There were 787 publications involved in this paper, comprising 745 articles and 42 reviews. China, the United States, and Germany are the primary publication sources in this area. Studies related to SLI primarily focused on mechanisms of pathogenesis, as evidenced by analyzing keywords, references, and the counting of original research. These studies mainly involved tumor necrosis factor alpha, inflammation, oxidative stress, and nuclear factor-kappa B.
There is significant growth in the research on SLI. Current investigations primarily involve basic experiments that aimed at uncovering pathogenic mechanisms. According to the analyzed literature, the identified pathogenic mechanisms and potential therapeutic targets serve as the foundation for translating findings from basic research to clinical applications.
脓毒症相关性肝损伤（SLI）是脓毒症的一种严重且普遍的并发症。
采用文献计量学方法探讨 SLI 的相关文献。
从 Web of Science 核心合集数据库中检索 2000 年 1 月 1 日至 2023 年 10 月 28 日与 SLI 相关的综述和文章，然后使用 VOSviewer、CiteSpace 和 R 语言对检索到的数据进行分析。
本文共纳入 787 篇文献，其中包括 745 篇文章和 42 篇综述。中国、美国和德国是该领域的主要出版来源国。对关键词、参考文献和原始研究的分析表明，与 SLI 相关的研究主要集中在发病机制上。这些研究主要涉及肿瘤坏死因子-α、炎症、氧化应激和核因子-κB。
关于 SLI 的研究呈显著增长趋势。目前的研究主要集中在基础实验上，旨在揭示发病机制。根据分析的文献，确定的发病机制和潜在的治疗靶点为将基础研究的发现转化为临床应用提供了基础。
