Jalal Sahbanathul Missiriya, Jalal Suhail Hassan, Alabdullatif Abeer Abbas, Alasmakh Kamilah Essa, Alnasser Zahraa Hussain, Alhamdan Wadiah Yousef
Department of Nursing, College of Applied Medical Sciences, King Faisal University, Al-Ahsa 31982, Saudi Arabia.
Department of Pharmacy, Jaya College of Pharmacy, The Tamil Nadu Dr. MGR Medical University, Chennai 602024, India.
J Clin Med. 2025 May 19;14(10):3555. doi: 10.3390/jcm14103555.
Sepsis, as a major cause of mortality worldwide, requires timely diagnosis and prompt treatment to improve patient outcomes. In this study, we evaluated sepsis management strategies and their impact on clinical outcomes in hospitalized patients. A retrospective study was conducted by analyzing clinical and treatment data from the electronic records of sepsis patients who had been admitted to tertiary care hospitals in eastern Saudi Arabia. Using systematic sampling, the details of eligible patients were obtained. Data were collected on patient demographics, vital signs, Sequential Organ Failure Assessment (SOFA) and laboratory parameters, treatment (antibiotic therapy, vasopressor use, or fluid resuscitation), and outcomes (survival in hospital). Statistical analyses were performed to assess the association between clinical and treatment strategies and patient outcomes. A total of 234 sepsis cases were analyzed, of which 70.9% were survivors and 29.1% were non-survivors. Patients aged 60 years and above were the most affected. Statistically significant differences were observed across all of the measured vital sign variables and outcomes ( < 0.0001). Based on SOFA scores, 56.41% of patients were assessed as having a moderate risk. Through our comparison of clinical and laboratory parameters between survivors and non-survivors, significant differences were found in all of the measured variables ( < 0.0001). The odds of survival were significantly higher in those who received early administration of broad-spectrum antibiotics (OR = 4.9449, = 0.0001), vasopressor therapy (OR = 1.9408, = 0.0262), and fluid resuscitation OR = 11.035, = 0.0001). The results of this study highlight the importance of early sepsis recognition, prompt antibiotic therapy, and standardized protocol adherence in improving patient outcomes and reducing mortality and morbidity.
脓毒症作为全球主要的死亡原因之一，需要及时诊断和迅速治疗以改善患者预后。在本研究中，我们评估了脓毒症的管理策略及其对住院患者临床结局的影响。通过分析沙特阿拉伯东部三级医院收治的脓毒症患者电子病历中的临床和治疗数据进行了一项回顾性研究。采用系统抽样方法获取符合条件患者的详细信息。收集了患者人口统计学资料、生命体征、序贯器官衰竭评估（SOFA）和实验室参数、治疗情况（抗生素治疗、血管活性药物使用或液体复苏）以及结局（住院存活情况）的数据。进行统计分析以评估临床和治疗策略与患者结局之间的关联。共分析了234例脓毒症病例，其中70.9%为存活者，29.1%为非存活者。60岁及以上患者受影响最大。在所有测量的生命体征变量和结局方面均观察到具有统计学意义的差异（<0.0001）。根据SOFA评分，56.41%的患者被评估为中度风险。通过比较存活者和非存活者的临床和实验室参数，发现在所有测量变量中均存在显著差异（<0.0001）。接受早期广谱抗生素治疗（OR = 4.9449，= 0.0001）、血管活性药物治疗（OR = 1.9408，= 0.0262）和液体复苏（OR = 11.035，= 0.0001）的患者存活几率显著更高。本研究结果强调了早期识别脓毒症、及时抗生素治疗以及遵循标准化方案在改善患者结局、降低死亡率和发病率方面的重要性。
