2003 年至 2021 年脑卒中后神经炎症中肿瘤坏死因子的文献计量学分析。

OBJECTIVE: Tumor necrosis factor (TNF), a crucial cytokine, has important research value in post-stroke neuroinflammation (PSN). We analyzed the studies that have been conducted in this area and used bibliometric methods to predict research hotspots and identify trends regarding TNF in PSN. METHODS: Publications were accessed at the Science Citation Index Expanded 1975-2021 (SCI expanded), Web of Science Core Collection (WoSCC), on May 1, 2022. Additionally, software such as CiteSpace and VOSviewer were utilized for bibliometric analyses. RESULTS: In total, 1391 original articles and reviews on TNF in PSN published from 2003 to 2021 were identified. An upward trend was observed in the number of publications on TNF in PSN. These publications were primarily from 57 countries and 1446 institutions, led by China and the United States with China leading the number of publications (NP) and the US with the number of citations (NC). The League of European Research Universities (LERU) and Journal of Neuroinflammation, respectively were the most prolific branches and journals. Zhang, John H. published the most papers and Finsen, Bente had the most cited papers. One paper by Kettenmann, H. published in 2011 reached the highest level of Global Citation Score (GCS). The keyword co-occurrence and reference co-citation analyses suggest that poststroke therapy and potential mechanistic pathways are important topics related to PSN in recent years. Reference burst detection suggests new burst hotspots after 2015, focusing on pathway modulation and discovery of therapeutic targets, suggesting a substantial development in the study of TNF in PSN research. CONCLUSION: The present bibliometric analysis shows a continuous trend of increasing literature related to TNF in PSN, and shows that TNF plays an important role in PSN involves multiple immune mechanisms and may contribute as a potential target for neuroprotective therapeutics after stroke. Prior to 2011, most of the research was focused on discovering the specific role of TNF in PSN, and in recent years studies have mainly targeted the exploration of the signaling pathways. Future research prospects may lie in finding key therapeutic targets in pathway of TNF in PSN.

目的：肿瘤坏死因子（TNF）作为一种关键的细胞因子，在后卒中神经炎症（PSN）中具有重要的研究价值。我们分析了该领域的研究，并使用文献计量学方法预测 TNF 在 PSN 中的研究热点和趋势。

方法：于 2022 年 5 月 1 日，在科学引文索引扩展版 1975-2021（SCI 扩展）和科学引文索引核心合集（WoSCC）中检索到 TNF 在后卒中神经炎症中的出版物。此外，还使用 CiteSpace 和 VOSviewer 等软件进行文献计量学分析。

结果：共确定了 2003 年至 2021 年 TNF 在后卒中神经炎症中的 1391 篇原始文章和综述。TNF 在后卒中神经炎症中的出版物数量呈上升趋势。这些出版物主要来自 57 个国家和 1446 个机构，中国和美国的出版物数量最多（NP），引文数量最多（NC）的是美国。欧洲研究型大学联盟（LERU）和神经炎症杂志分别是最具影响力的分支和期刊。Zhang，John H. 发表的论文最多，Finsen，Bente 被引论文最多。Kettenmann，H. 于 2011 年发表的一篇论文达到了全球引文得分（GCS）的最高水平。关键词共现和参考文献共引分析表明，近年来，卒中后治疗和潜在的机制途径是与 PSN 相关的重要主题。参考文献突发检测表明，2015 年后出现了新的突发热点，重点是途径调节和治疗靶点的发现，这表明 TNF 在 PSN 研究中的研究有了很大的发展。

结论：本文献计量分析表明，与 TNF 在后卒中神经炎症相关的文献呈持续增加趋势，表明 TNF 在 PSN 中发挥着重要作用，涉及多种免疫机制，并可能作为卒中后神经保护治疗的潜在靶点。2011 年之前，大部分研究侧重于发现 TNF 在 PSN 中的特定作用，近年来的研究主要针对信号通路的探索。未来的研究前景可能在于发现 TNF 在 PSN 信号通路中的关键治疗靶点。