Division of Carcinogenesis and Senescence Biology, Tohoku University Graduate School of Medicine, Natori 981-1293, Miyagi, Japan.
Division of Cancer Stem Cell, Miyagi Cancer Center Research Institute, Natori 981-1293, Miyagi, Japan.
World J Gastroenterol. 2024 Aug 14;30(30):3625-3627. doi: 10.3748/wjg.v30.i30.3625.
In this issue of , Huang reported that Calculus bovis (CB), a traditional Chinese herbal medicine, impedes the growth of liver cancers . Through further studies, they showed that CB suppressed the M2 polarization of tumor-associated macrophages by suppressing the Wnt signaling pathway, which consequently inhibited the growth of liver cancer. Although the effects of traditional Chinese herbal medicine are often not scientifically proven, Huang successfully identified the molecular mechanism involved in the anticancer effect of CB, and it is anticipated that the molecular mechanisms involved in the effects of other traditional Chinese herbal medicines will be scientifically elucidated, as demonstrated in this article.
本期 杂志中，Huang 报道称，中药牛黄（CB）能阻碍肝癌的生长。通过进一步研究，他们发现 CB 通过抑制 Wnt 信号通路抑制肿瘤相关巨噬细胞的 M2 极化，从而抑制肝癌的生长。虽然中药的疗效往往没有科学依据，但 Huang 成功地鉴定了 CB 抗癌作用的分子机制，预计其他中药的作用机制也将像本文一样得到科学阐明。
