Zhan T, Rindtorff N, Boutros M
German Cancer Research Center (DKFZ), Division Signaling and Functional Genomics, Heidelberg University, Department Cell and Molecular Biology, Faculty of Medicine Mannheim, Heidelberg, Germany.
Heidelberg University, Department of Internal Medicine II, Medical Faculty Mannheim, Mannheim, Germany.
Oncogene. 2017 Mar;36(11):1461-1473. doi: 10.1038/onc.2016.304. Epub 2016 Sep 12.
Wnt signaling is one of the key cascades regulating development and stemness, and has also been tightly associated with cancer. The role of Wnt signaling in carcinogenesis has most prominently been described for colorectal cancer, but aberrant Wnt signaling is observed in many more cancer entities. Here, we review current insights into novel components of Wnt pathways and describe their impact on cancer development. Furthermore, we highlight expanding functions of Wnt signaling for both solid and liquid tumors. We also describe current findings how Wnt signaling affects maintenance of cancer stem cells, metastasis and immune control. Finally, we provide an overview of current strategies to antagonize Wnt signaling in cancer and challenges that are associated with such approaches.
Wnt信号通路是调控发育和干性的关键级联反应之一，并且也与癌症紧密相关。Wnt信号通路在致癌作用中的作用在结直肠癌中得到了最为突出的描述，但在更多的癌症实体中也观察到了Wnt信号通路的异常。在此，我们综述了对Wnt通路新成分的当前见解，并描述了它们对癌症发展的影响。此外，我们强调了Wnt信号通路在实体瘤和液体瘤中的扩展功能。我们还描述了Wnt信号通路如何影响癌症干细胞的维持、转移和免疫控制的当前研究结果。最后，我们概述了当前在癌症中拮抗Wnt信号通路的策略以及与此类方法相关的挑战。
