• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

信息处理速度在遗忘型轻度认知障碍中脑重构与情景记忆关系中的调节作用。

The moderating role of information processing speed in the relationship between brain remodeling and episodic memory in amnestic mild cognitive impairment.

机构信息

Department of Rehabilitation Medicine, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

School of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

出版信息

Alzheimers Dement. 2024 Oct;20(10):6793-6809. doi: 10.1002/alz.14130. Epub 2024 Aug 28.

DOI:10.1002/alz.14130
PMID:39193657
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11485304/
Abstract

INTRODUCTION

The role of information processing speed (IPS) on relationships between episodic memory (EM) and central remodeling features in amnestic mild cognitive impairment (aMCI) was investigated.

METHODS

Neuropsychological evaluations and multimodal magnetic resonance imaging were performed on 48 patients diagnosed with aMCI and 50 healthy controls (HC). Moderation models explored the moderating effect of IPS on associations between EM and imaging features at single-region, connectivity, and network levels.

RESULTS

IPS significantly enhanced the positive correlations between recall and cortical thickness of left inferior temporal gyrus. IPS also notably amplified negative correlations between recognition and functional connectivity (FC) of left inferior parietal lobe and right occipital, as well as between recall/recognition and nodal clustering coefficient of left anterior cingulate cortex.

DISCUSSION

IPS functioned as a moderator of associations between recall and neuroimaging metrics at the "single region-connectivity-network" level, providing new insights for cognitive rehabilitation in aMCI patients.

HIGHLIGHTS

aMCI patients exhibited brain functional and structural remodeling alterations. IPS moderated relations between episodic memory and brain remodeling metrics. Therapy targeted at IPS can be considered for improving episodic memory in aMCI.

摘要

简介

本研究旨在探讨信息处理速度（IPS）对遗忘型轻度认知障碍（aMCI）患者情景记忆（EM）与中心重塑特征之间关系的作用。

方法

对 48 名被诊断为 aMCI 的患者和 50 名健康对照者（HC）进行神经心理学评估和多模态磁共振成像。采用调节模型探讨 IPS 对 EM 与单区域、连接和网络水平的影像学特征之间关联的调节作用。

结果

IPS 显著增强了回忆与左颞下回皮质厚度之间的正相关。IPS 还显著放大了识别与左顶下叶和右枕叶功能连接（FC）以及回忆/识别与左前扣带回节点聚类系数之间的负相关。

讨论

IPS 作为回忆与“单区域-连接-网络”水平的神经影像学指标之间关联的调节者，为 aMCI 患者的认知康复提供了新的见解。

要点

aMCI 患者表现出脑功能和结构重塑改变。IPS 调节了情景记忆与脑重塑指标之间的关系。针对 IPS 的治疗可以考虑用于改善 aMCI 患者的情景记忆。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a9e0/11485304/b082e501d8b4/ALZ-20-6793-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a9e0/11485304/c1ba426a360c/ALZ-20-6793-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a9e0/11485304/fdca338c5fa4/ALZ-20-6793-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a9e0/11485304/8f3f617b9778/ALZ-20-6793-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a9e0/11485304/2adb9a403f85/ALZ-20-6793-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a9e0/11485304/c4f9f3acf1e0/ALZ-20-6793-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a9e0/11485304/f60fcd46e904/ALZ-20-6793-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a9e0/11485304/b082e501d8b4/ALZ-20-6793-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a9e0/11485304/c1ba426a360c/ALZ-20-6793-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a9e0/11485304/fdca338c5fa4/ALZ-20-6793-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a9e0/11485304/8f3f617b9778/ALZ-20-6793-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a9e0/11485304/2adb9a403f85/ALZ-20-6793-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a9e0/11485304/c4f9f3acf1e0/ALZ-20-6793-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a9e0/11485304/f60fcd46e904/ALZ-20-6793-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a9e0/11485304/b082e501d8b4/ALZ-20-6793-g002.jpg

相似文献

1
The moderating role of information processing speed in the relationship between brain remodeling and episodic memory in amnestic mild cognitive impairment.信息处理速度在遗忘型轻度认知障碍中脑重构与情景记忆关系中的调节作用。
Alzheimers Dement. 2024 Oct;20(10):6793-6809. doi: 10.1002/alz.14130. Epub 2024 Aug 28.
2
Episodic memory network characteristics in patients with amnestic mild cognitive impairment accompanied by executive function impairment.遗忘型轻度认知损害伴执行功能损害患者的情景记忆网络特征。
Brain Behav. 2024 Jun;14(6):e3601. doi: 10.1002/brb3.3601.
3
Mediation of episodic memory performance by the executive function network in patients with amnestic mild cognitive impairment: a resting-state functional MRI study.遗忘型轻度认知障碍患者情景记忆表现受执行功能网络的介导作用：一项静息态功能磁共振成像研究
Oncotarget. 2016 Oct 4;7(40):64711-64725. doi: 10.18632/oncotarget.11775.
4
State-based functional connectivity changes associate with cognitive decline in amnestic mild cognitive impairment subjects.基于状态的功能连接变化与遗忘型轻度认知障碍受试者的认知衰退相关。
Behav Brain Res. 2015 Jul 15;288:94-102. doi: 10.1016/j.bbr.2015.04.013. Epub 2015 Apr 20.
5
Resting state functional connectivity abnormalities and delayed recall performance in patients with amnestic mild cognitive impairment.遗忘型轻度认知障碍患者的静息状态功能连接异常和延迟回忆表现。
Brain Imaging Behav. 2020 Feb;14(1):267-277. doi: 10.1007/s11682-018-9974-1.
6
Neural correlates of autobiographical memory in amnestic Mild Cognitive Impairment.遗忘型轻度认知障碍患者自传体记忆的神经相关物。
Psychiatry Res. 2012 Feb 28;201(2):159-67. doi: 10.1016/j.pscychresns.2011.06.007. Epub 2012 Mar 14.
7
Tongue coating-dependent superior temporal sulcus remodeling in amnestic mild cognitive impairment.遗忘型轻度认知障碍中与舌苔相关的 Superior Temporal Sulcus 重塑。
Brain Res Bull. 2024 Aug;214:110995. doi: 10.1016/j.brainresbull.2024.110995. Epub 2024 Jun 4.
8
Connectome-based model predicts episodic memory performance in individuals with subjective cognitive decline and amnestic mild cognitive impairment.基于连接组学的模型预测有主观认知下降和遗忘型轻度认知障碍个体的情景记忆表现。
Behav Brain Res. 2021 Aug 6;411:113387. doi: 10.1016/j.bbr.2021.113387. Epub 2021 May 25.
9
Convergent and divergent intranetwork and internetwork connectivity patterns in patients with remitted late-life depression and amnestic mild cognitive impairment.缓解期老年抑郁症和遗忘型轻度认知障碍患者的网络内和网络间汇聚与发散连接模式
Cortex. 2016 Oct;83:194-211. doi: 10.1016/j.cortex.2016.08.001. Epub 2016 Aug 10.
10
Deficits in episodic memory retrieval reveal impaired default mode network connectivity in amnestic mild cognitive impairment.情景记忆检索缺陷揭示了遗忘型轻度认知障碍患者默认模式网络连接受损。
Neuroimage Clin. 2014 Feb 27;4:473-80. doi: 10.1016/j.nicl.2014.02.010. eCollection 2014.

引用本文的文献

1
Functional-structural co-dependent brain mapping of metamemory in amnestic mild cognitive impairment.遗忘型轻度认知障碍中记忆元认知的功能-结构相互依赖脑图谱
Alzheimers Res Ther. 2025 Jul 18;17(1):164. doi: 10.1186/s13195-025-01816-5.
2
Examining Specific Theory-of-Mind Aspects in Amnestic and Non-Amnestic Mild Cognitive Impairment: Their Relationships with Sleep Duration and Cognitive Planning.探究遗忘型和非遗忘型轻度认知障碍中的特定心理理论方面：它们与睡眠时间和认知规划的关系。
Brain Sci. 2025 Jan 10;15(1):57. doi: 10.3390/brainsci15010057.

本文引用的文献

1
Mapping the long-term delayed recall-based cortex-hippocampus network constrained by the structural and functional connectome: a case-control multimodal MRI study.基于结构和功能连接组学约束的长期延迟回忆型皮质-海马网络图谱：一项病例对照多模态 MRI 研究。
Alzheimers Res Ther. 2023 Mar 24;15(1):61. doi: 10.1186/s13195-023-01197-7.
2
Functional and structural alterations of dorsal attention network in preclinical and early-stage Alzheimer's disease.在临床前和早期阿尔茨海默病中背侧注意网络的功能和结构改变。
CNS Neurosci Ther. 2023 Jun;29(6):1512-1524. doi: 10.1111/cns.14092. Epub 2023 Mar 21.
3
RESTplus: an improved toolkit for resting-state functional magnetic resonance imaging data processing.
RESTplus：一种用于静息态功能磁共振成像数据处理的改进工具包。
Sci Bull (Beijing). 2019 Jul 30;64(14):953-954. doi: 10.1016/j.scib.2019.05.008. Epub 2019 May 13.
4
Altered anterior cingulate cortex subregional connectivity associated with cognitions for distinguishing the spectrum of pre-clinical Alzheimer's disease.前扣带回皮质亚区域连接改变与区分临床前阿尔茨海默病谱系的认知相关。
Front Aging Neurosci. 2022 Dec 7;14:1035746. doi: 10.3389/fnagi.2022.1035746. eCollection 2022.
5
Brain atrophy pattern in patients with mild cognitive impairment: MRI study.轻度认知障碍患者的脑萎缩模式：MRI研究
Transl Neurosci. 2022 Sep 27;13(1):335-348. doi: 10.1515/tnsci-2022-0248. eCollection 2022 Jan 1.
6
Concurrent Structural and Functional Patterns in Patients With Amnestic Mild Cognitive Impairment.遗忘型轻度认知障碍患者的并发结构和功能模式
Front Aging Neurosci. 2022 May 17;14:838161. doi: 10.3389/fnagi.2022.838161. eCollection 2022.
7
Time perspective and amnestic mild cognitive impairment.时间观与遗忘型轻度认知损害。
J Neuropsychol. 2022 Sep;16(3):463-480. doi: 10.1111/jnp.12274. Epub 2022 Feb 16.
8
Neurons in the human medial temporal lobe track multiple temporal contexts during episodic memory processing.人类内侧颞叶中的神经元在情节记忆处理过程中跟踪多个时间背景。
Neuroimage. 2021 Dec 15;245:118689. doi: 10.1016/j.neuroimage.2021.118689. Epub 2021 Nov 3.
9
Reduced Thickness of the Anterior Cingulate Cortex as a Predictor of Amnestic-Mild Cognitive Impairment Conversion to Alzheimer's Disease with Psychosis.前扣带回皮质变薄可预测遗忘型轻度认知障碍向伴有精神病症状的阿尔茨海默病转化。
J Alzheimers Dis. 2021;84(4):1709-1717. doi: 10.3233/JAD-215005.
10
Disrupted Dynamic Functional Connectivity in Distinguishing Subjective Cognitive Decline and Amnestic Mild Cognitive Impairment Based on the Triple-Network Model.基于三网络模型区分主观认知衰退和遗忘型轻度认知障碍时动态功能连接的破坏
Front Aging Neurosci. 2021 Sep 17;13:711009. doi: 10.3389/fnagi.2021.711009. eCollection 2021.