Calandrelli Rosalinda, Panfili Marco, Onofrj Valeria, Tran Huong Elena, Piludu Francesca, Guglielmi Valeria, Colosimo Cesare, Pilato Fabio
Dipartimento di Diagnostica per Immagini, Radioterapia, Oncologia ed Ematologia, Institute of Radiology, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Largo A. Gemelli, 1, 00168 Rome, Italy.
Department of Medical Imaging, Cliniques Universitaires Saint-Luc, Brussels, Belgium.
Transl Neurosci. 2022 Sep 27;13(1):335-348. doi: 10.1515/tnsci-2022-0248. eCollection 2022 Jan 1.
We evaluated the accuracy of the quantitative and semiquantitative analysis in detecting regional atrophy patterns and differentiating mild cognitive impairment patients who remain stable (aMCI-S) from patients who develop Alzheimer's disease (aMCI-AD) at clinical follow-up. Baseline magnetic resonance imaging was used for quantitative and semiquantitative analysis using visual rating scales. Visual rating scores were related to gray matter thicknesses or volume measures of some structures belonging to the same brain regions. Receiver operating characteristic (ROC) analysis was performed to assess measures' accuracy in differentiating aMCI-S from aMCI-AD. Comparing aMCI-S and aMCI-AD patients, significant differences were found for specific rating scales, for cortical thickness belonging to the middle temporal lobe (MTL), anterior temporal (AT), and fronto-insular (FI) regions, for gray matter volumes belonging to MTL and AT regions. ROC curve analysis showed that middle temporal atrophy, AT, and FI visual scales showed better diagnostic accuracy than quantitative measures also when thickness measures were combined with hippocampal volumes. Semiquantitative evaluation, performed by trained observers, is a fast and reliable tool in differentiating, at the early stage of disease, aMCI patients that remain stable from those patients that may progress to AD since visual rating scales may be informative both about early hippocampal volume loss and cortical thickness reduction.
我们评估了定量和半定量分析在检测区域萎缩模式以及在临床随访中区分病情保持稳定的轻度认知障碍患者（稳定型轻度认知障碍，aMCI-S）和发展为阿尔茨海默病的患者（进展型轻度认知障碍，aMCI-AD）方面的准确性。使用基线磁共振成像，通过视觉评分量表进行定量和半定量分析。视觉评分与属于同一脑区的某些结构的灰质厚度或体积测量值相关。进行受试者工作特征（ROC）分析以评估这些测量方法在区分aMCI-S和aMCI-AD方面的准确性。比较aMCI-S和aMCI-AD患者，发现特定评分量表、颞中回（MTL）、颞前叶（AT）和额岛叶（FI）区域的皮质厚度、MTL和AT区域的灰质体积存在显著差异。ROC曲线分析表明，当厚度测量值与海马体积相结合时，颞中回萎缩、AT和FI视觉量表显示出比定量测量更好的诊断准确性。由训练有素的观察者进行的半定量评估是一种快速且可靠的工具，可在疾病早期区分病情保持稳定的aMCI患者和可能进展为AD的患者，因为视觉评分量表可能对早期海马体积损失和皮质厚度减少都有提示作用。
