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Leveraging multi-cancer blood tests to improve diagnostic efficiency for patients with nonspecific signs and symptoms.

作者信息

Singal Amit G, Kurtzman Kathryn N, Thompson Matthew J

机构信息

Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX 75390, USA.

GRAIL, Inc., Menlo Park, CA 94025, USA.

出版信息

Future Oncol. 2024;20(34):2603-2607. doi: 10.1080/14796694.2024.2388505. Epub 2024 Aug 28.

DOI:10.1080/14796694.2024.2388505
PMID:39193702
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11534101/
Abstract
摘要

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Shifting the Cancer Screening Paradigm: Developing a Multi-Biomarker Class Approach to Multi-Cancer Early Detection Testing.转变癌症筛查模式：开发用于多癌早期检测测试的多生物标志物分类方法。
Life (Basel). 2024 Jul 24;14(8):925. doi: 10.3390/life14080925.
2
Blood-based tests for multicancer early detection (PATHFINDER): a prospective cohort study.基于血液的多种癌症早期检测（PATHFINDER）：一项前瞻性队列研究。
Lancet. 2023 Oct 7;402(10409):1251-1260. doi: 10.1016/S0140-6736(23)01700-2.
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Cell-free DNA approaches for cancer early detection and interception.无细胞游离 DNA 方法在癌症早期检测和干预中的应用。
J Immunother Cancer. 2023 Sep;11(9). doi: 10.1136/jitc-2022-006013.
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Performance of a Cell-Free DNA-Based Multi-cancer Detection Test in Individuals Presenting With Symptoms Suspicious for Cancers.基于游离细胞 DNA 的多癌种检测试验在出现疑似癌症症状的个体中的表现。
JCO Precis Oncol. 2023 Jul;7:e2200679. doi: 10.1200/PO.22.00679.
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Multi-cancer early detection test in symptomatic patients referred for cancer investigation in England and Wales (SYMPLIFY): a large-scale, observational cohort study.英国和威尔士因癌症检查而转诊的有症状患者的多癌早期检测试验（SYMPLIFY）：一项大规模观察性队列研究
Lancet Oncol. 2023 Jul;24(7):733-743. doi: 10.1016/S1470-2045(23)00277-2. Epub 2023 Jun 20.
6
Clinical validation of a targeted methylation-based multi-cancer early detection test using an independent validation set.使用独立验证集对靶向甲基化的多癌种早期检测测试进行临床验证。
Ann Oncol. 2021 Sep;32(9):1167-1177. doi: 10.1016/j.annonc.2021.05.806. Epub 2021 Jun 24.
7
Reviewing the impact of 11 national Be Clear on Cancer public awareness campaigns, England, 2012 to 2016: A synthesis of published evaluation results.审查 11 项全国“爱康工程”公众宣传活动对英格兰的影响，2012 年至 2016 年：已发表评估结果的综合报告。
Int J Cancer. 2021 Mar 1;148(5):1172-1182. doi: 10.1002/ijc.33277. Epub 2020 Nov 7.
8
Feasibility of blood testing combined with PET-CT to screen for cancer and guide intervention.血液检测结合 PET-CT 筛查癌症并指导干预的可行性。
Science. 2020 Jul 3;369(6499). doi: 10.1126/science.abb9601. Epub 2020 Apr 28.
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The frequency, nature and impact of GP-assessed avoidable delays in a population-based cohort of cancer patients.基于人群的癌症患者队列中全科医生评估的可避免延迟的频率、性质和影响。
Cancer Epidemiol. 2020 Feb;64:101617. doi: 10.1016/j.canep.2019.101617. Epub 2019 Dec 3.
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