Huang Yuqing, Meng Chen, Yan Bing, Wang Chengshuo, Zhang Luo
Department of Otolaryngology，Head and Neck Surgery，Beijing Tongren Hospital，Capital Medical University，Beijing，100730，China.
Beijing Institute of Otolaryngology，Beijing Laboratoryof Allergic Diseases，Beijing Key Laboratory of Nasal Diseases，Key Laboratory of Otolaryngology Head and Neck Surgery，Ministry of Education，Capital Medical University.
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2024 Sep;38(9):872-878;882. doi: 10.13201/j.issn.2096-7993.2024.09.019.
Chronic rhinosinusitis with nasal polyps is a common chronic inflammatory disease with significant tissue remodeling, but the mechanism of remodeling remains unclear. Studies have shown that Type（T） 2 inflammatory network plays a crucial role in tissue remodeling and nasal polyp formation. Clinical trials have been carried out for several biological targets, and a number of potential therapeutic targets have received increasing attention. This paper will summarize the research progress of T2 inflammatory response involved in nasal polyp tissue remodeling to provide ideas for further exploring the mechanism of nasal polyp tissue remodeling.
伴有鼻息肉的慢性鼻-鼻窦炎是一种常见的慢性炎症性疾病，伴有显著的组织重塑，但重塑机制仍不清楚。研究表明，2型（T）炎症网络在组织重塑和鼻息肉形成中起关键作用。针对多个生物学靶点开展了临床试验，一些潜在治疗靶点受到越来越多关注。本文将总结参与鼻息肉组织重塑的2型炎症反应的研究进展，为进一步探究鼻息肉组织重塑机制提供思路。
