Global Health and Migration Unit, Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
Maternal and Child Health Division, International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.
Glob Health Action. 2024 Dec 31;17(1):2390269. doi: 10.1080/16549716.2024.2390269. Epub 2024 Aug 28.
Anaemia is commonly caused by iron deficiency and screened by haemoglobin (Hb) concentration in blood. There is a scarcity of longitudinal data on the relationship between maternal Hb levels during pregnancy and neurodevelopment in children.
To measure the relationship of maternal Hb concentrations during pregnancy on early child development.
This prospective cohort study included 1,720 mother-child dyads in rural Bangladesh. Maternal Hb concentrations were measured at 14 and 30 weeks of gestation. The child's Mental Developmental Index (MDI) and Psychomotor Developmental Index (PDI) at 18 months of age were measured using Bayley Scales of Infant and Toddler Development (BSID-II). Data on socio-demographic characteristics, anthropometrics, mothers' IQ and children's home stimulation were also collected. Bivariate and multivariable-adjusted linear regression analyses were used to explore associations of maternal Hb with child development.
Mean Hb concentrations at 14 and 30 weeks of gestation were 116.6 g/L (±12.7) and 114.7 g/L (±12.7), respectively. Mean MDI and PDI scores among 18-month-old children were 78.9 (±12.4) and 93.8 (±13.7), respectively. Maternal 14-week Hb concentration was correlated with PDI ( = 0.06; < 0.05) and 30-week Hb concentrations was correlated with MDI ( = 0.05; < 0.05). Multivariable adjusted linear regression analysis showed that an increase in 14-week Hb concentrations increased the PDI scores among boys (β = 0.09; 95% CI: 0.02, 0.16). Hb concentrations at 30 weeks of gestation were not associated with MDI or PDI scores.
Higher maternal Hb concentrations at 14 weeks of gestation were associated with higher PDI among 18-month-old boys in Bangladesh.
贫血通常是由缺铁引起的，可以通过血液中的血红蛋白（Hb）浓度进行筛查。然而，关于孕妇怀孕期间 Hb 水平与儿童神经发育之间关系的纵向数据却十分匮乏。
测量孕妇怀孕期间 Hb 浓度与儿童早期发育之间的关系。
本前瞻性队列研究纳入了孟加拉国农村地区的 1720 对母婴对子。在妊娠 14 周和 30 周时测量了母亲的 Hb 浓度。在 18 个月时使用贝利婴幼儿发育量表（BSID-II）测量了儿童的心理发育指数（MDI）和精神运动发育指数（PDI）。还收集了社会人口特征、人体测量学、母亲智商和儿童家庭刺激的数据。采用双变量和多变量调整线性回归分析来探讨母亲 Hb 与儿童发育之间的关联。
妊娠 14 周和 30 周时的平均 Hb 浓度分别为 116.6 g/L（±12.7）和 114.7 g/L（±12.7）。18 个月大的儿童的平均 MDI 和 PDI 评分分别为 78.9（±12.4）和 93.8（±13.7）。母亲 14 周 Hb 浓度与 PDI 呈正相关（ = 0.06； < 0.05），30 周 Hb 浓度与 MDI 呈正相关（ = 0.05； < 0.05）。多变量调整线性回归分析显示，14 周 Hb 浓度升高使男孩的 PDI 评分升高（β = 0.09；95% CI：0.02，0.16）。妊娠 30 周时的 Hb 浓度与 MDI 或 PDI 评分无关。
孟加拉国 18 个月大的男童妊娠 14 周时的母亲 Hb 浓度较高与 PDI 较高有关。
