Thomas M G, Giles T D
South Med J. 1985 Feb;78(2):205-6. doi: 10.1097/00007611-198502000-00024.
The use of class 1A antidysrhythmic agents in patients with or without prolonged QT intervals carries a risk of induction of polymorphic ventricular tachycardia. The class 1B antidysrhythmics have many similarities to the former group, but have different modes of action and electrophysiologic properties. Therefore, lidocaine and lidocaine-like drugs such as mexiletine may be used with relative safety in this clinical situation, as in the case we have reported, in which lidocaine and mexiletine controlled VPB in the acute stage and during long-term follow-up respectively, while quinidine induced "torsades de pointes."
1A类抗心律失常药物用于有或无QT间期延长的患者时，有诱发多形性室性心动过速的风险。1B类抗心律失常药物与前一组有许多相似之处，但作用方式和电生理特性不同。因此，利多卡因和利多卡因样药物（如美西律）在这种临床情况下使用可能相对安全，就像我们报道的病例那样，利多卡因和美西律分别在急性期和长期随访期间控制室性早搏，而奎尼丁诱发了“尖端扭转型室速”。
