Cocco G, Strozzi C, Chu D, Pansini R
Am Heart J. 1980 Dec;100(6 Pt 1):878-80. doi: 10.1016/0002-8703(80)90070-8.
An episode of torsades de pointes, an unusual ventricular tachyarrhythmia, developed in a 59-year-old coronary patient who was treated with 100 mg. four times a day mexiletine orally. The PR, QRS, and QT intervals were normal. The ventricular arrhythmias resembled in part, the patient's previous ventricular premature complexes, but there were some relevant morphological differences. The plasma electrolytes were within normal limits. Mexiletine, which is chemically and electrophysiologically similar to lidocaine, probably caused this arrhythmia. Although mexiletine is a useful antiarrhythmic drug, it should be added to the list of drugs associated with atypical ventricular tachycardia.
一名59岁的冠心病患者在口服美西律每日4次、每次100毫克治疗期间，发生了一次尖端扭转型室速，这是一种不常见的室性快速心律失常。PR、QRS和QT间期均正常。室性心律失常部分类似于患者既往的室性早搏，但存在一些相关的形态学差异。血浆电解质在正常范围内。美西律在化学和电生理方面与利多卡因相似，可能导致了这种心律失常。虽然美西律是一种有用的抗心律失常药物，但它应被列入与非典型室性心动过速相关的药物名单中。
