Guarienti Fabiana Amaral, Xavier Fernando Antônio Costa, Ferraz Mateus Duarte, Wagner Fernanda, Marinowic Daniel Rodrigo, da Costa Jaderson Costa, Machado Denise Cantarelli
Post Graduation Program of Geriatrics and Gerontology, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre 90619, Brazil.
Laboratory of Molecular Biology and Immunology, Brain Institute of Rio Grande do Sul, Porto Alegre 90610, Brazil.
Curr Issues Mol Biol. 2024 Jul 28;46(8):8111-8117. doi: 10.3390/cimb46080480.
Regardless of the containment of the SARS-CoV-2 pandemic, it remains paramount to comprehensively understand its underlying mechanisms to mitigate potential future health and economic impacts, comparable to those experienced throughout the course of the pandemic. The angiotensin-converting enzyme 2 (ACE2) provides anchorage for SARS-CoV-2 binding, thus implicating that ACE and ACE2 might contribute to the variability in infection severity. This study aimed to elucidate predisposing factors influencing the disease course among people infected by SARS-CoV-2, focusing on angiotensin-converting enzyme (ACE) and ACE2 polymorphisms. Notably, despite similar demographics and comorbidities, COVID-19 patients exhibit substantial differences in prognosis. Genetic polymorphisms in ACE and ACE2 have been implicated in disease progression, prompting our investigation into their role in COVID-19 evolution. Using next-generation sequencing (NGS), we analyzed ACE and ACE2 genes in a sample group comprising six subjects infected by SARS-CoV-2. Our findings revealed a correlation between specific polymorphisms and COVID-19 outcomes. Specifically, ACE and ACE2 intronic deletions were observed in all deceased patients, suggesting a potential association with mortality. These results highlight the significance of genetic factors in shaping the clinical course of COVID-19, emphasizing the importance of further research into the impact of genetic variations on COVID-19 severity.
无论严重急性呼吸综合征冠状病毒2（SARS-CoV-2）大流行是否得到控制，全面了解其潜在机制对于减轻未来可能的健康和经济影响仍然至关重要，这些影响与大流行期间所经历的影响相当。血管紧张素转换酶2（ACE2）为SARS-CoV-2结合提供锚定，因此表明ACE和ACE2可能导致感染严重程度的差异。本研究旨在阐明影响SARS-CoV-2感染者疾病进程的易感因素，重点关注血管紧张素转换酶（ACE）和ACE2基因多态性。值得注意的是，尽管新冠肺炎患者的人口统计学特征和合并症相似，但他们在预后方面存在显著差异。ACE和ACE2基因多态性与疾病进展有关，这促使我们研究它们在新冠肺炎演变中的作用。我们使用下一代测序（NGS）技术，对一个由六名SARS-CoV-2感染者组成的样本组中的ACE和ACE2基因进行了分析。我们的研究结果揭示了特定基因多态性与新冠肺炎预后之间的相关性。具体而言，在所有死亡患者中均观察到ACE和ACE2内含子缺失现象，这表明其可能与死亡率有关。这些结果凸显了遗传因素在塑造新冠肺炎临床进程中的重要性，并强调了进一步研究基因变异对新冠肺炎严重程度影响的重要性。
