Lossavaro Paloma Kênia de Moraes Berenguel, Felipe Josyelen Lousada, Lencina Joyce Dos Santos, Bonfá Iluska Senna, de Souza Kamylla Fernanda Souza, Machado Lucas Luiz, Fernandes Mila Marluce Lima, Ferreira João Victor, Souza Maria Inês Lenz, Candeloro Luciane, Kassuya Cândida Aparecida Leite, Paredes-Gamero Edgar Julian, Parisotto Eduardo Benedetti, Toffoli-Kadri Mônica Cristina, Silva-Filho Saulo Euclides
Pharmaceutical Sciences, Food and Nutrition College, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, MS, Brazil.
Biosciences Institute, Federal University of Mato Grosso do Sul, Campo Grande 79070-900, MS, Brazil.
Curr Issues Mol Biol. 2024 Aug 18;46(8):9033-9046. doi: 10.3390/cimb46080534.
The aim of this study was to evaluate the effect of ylang-ylang () essential oil (YEO) on models of experimental arthritis, persistent inflammation, and nociception in mice. YEO treatment at doses of 100 and 200 mg/kg reduced the infiltration of leukocytes into the joint cavities of mice submitted to zymosan-induced arthritis 6 h and 7 days after arthritis induction. At these doses, YEO treatment reduced the formation of joint edema 4 and 6 h after arthritis induction, and at a dose of 200 mg/kg, YEO treatment reduced mechanical hyperalgesia 3 and 4 h after arthritis induction. At the dose of 200 mg/kg, YEO treatment reduced interleukin-6 (IL-6) levels and cartilage destruction in the zymosan-induced arthritis model, and reduced edema formation and mechanical hyperalgesia in the model of persistent inflammation (21 days) induced by complete Freund's adjuvant (CFA) in mice. YEO treatment at a dose of 200 mg/kg reduced the nociceptive response in experimental models of nociception induced by acetic acid and formalin. The YEO treatment reduced inflammatory parameters in the experimental arthritis model, and presented antiarthritic, anti-hyperalgesic, antinociceptive, and anti-inflammatory properties.
本研究的目的是评估依兰依兰（）精油（YEO）对小鼠实验性关节炎、持续性炎症和痛觉过敏模型的影响。在诱导关节炎后6小时和7天，给予100和200mg/kg剂量的YEO治疗可减少酵母聚糖诱导的关节炎小鼠关节腔内白细胞的浸润。在这些剂量下，YEO治疗可在关节炎诱导后4小时和6小时减少关节水肿的形成，在200mg/kg剂量下，YEO治疗可在关节炎诱导后3小时和4小时减少机械性痛觉过敏。在200mg/kg剂量下，YEO治疗可降低酵母聚糖诱导的关节炎模型中白细胞介素-6（IL-6）水平和软骨破坏，并减少小鼠完全弗氏佐剂（CFA）诱导的持续性炎症（21天）模型中的水肿形成和机械性痛觉过敏。200mg/kg剂量的YEO治疗可降低乙酸和福尔马林诱导的痛觉过敏实验模型中的伤害性反应。YEO治疗可降低实验性关节炎模型中的炎症参数，并具有抗关节炎、抗痛觉过敏、抗伤害性和抗炎特性。
