Gambale Carla, Rocha José Vicente, Prete Alessandro, Minaldi Elisa, Elisei Rossella, Matrone Antonio
Unit of Endocrinology, Department of Clinical and Experimental Medicine, Pisa University Hospital, 56124 Pisa, Italy.
Serviço de Endocrinologia, Diabetes e Metabolismo, Unidade Local de Saúde Santa Maria, 1649-028 Lisboa, Portugal.
J Imaging. 2024 Aug 5;10(8):189. doi: 10.3390/jimaging10080189.
Thyroid nodules in pediatric patients are less common than in adults but show a higher malignancy rate. Accordingly, the management of thyroid nodules in pediatric patients is more complex the younger the patient is, needing careful evaluation by physicians. In adult patients, specific ultrasound (US) features have been associated with an increased risk of malignancy (ROM) in thyroid nodules. Moreover, several US risk stratification systems (RSSs) combining the US features of the nodule were built to define the ROM. RSSs are developed for the adult population and their use has not been fully validated in pediatric patients. This study aimed to evaluate the available data about US features of thyroid nodules in pediatric patients and to provide a summary of the evidence regarding the performance of RSS in predicting malignancy. Moreover, insights into the management of thyroid nodules in pediatric patients will be provided.
儿童甲状腺结节比成人少见，但恶性率更高。因此，儿童患者年龄越小，甲状腺结节的管理就越复杂，需要医生进行仔细评估。在成年患者中，特定的超声（US）特征与甲状腺结节恶性风险增加相关。此外，构建了几种结合结节US特征的US风险分层系统（RSS）来定义恶性风险。RSS是针对成年人群开发的，其在儿科患者中的应用尚未得到充分验证。本研究旨在评估有关儿科患者甲状腺结节US特征的现有数据，并总结关于RSS预测恶性肿瘤性能的证据。此外，还将提供有关儿科患者甲状腺结节管理的见解。
