Rasouli Nafee, Malakouti Seyed Kazem, Bayat Masoumeh, Mahjoubnavaz Firouzeh, Fallahinia Niloofar, Khosrowabadi Reza
Department of Clinical Psychology, School of Behavioral Sciences and Mental Health, Iran University of Medical Sciences, Tehran, Iran.
Geriatric Mental Health Research Center, School of Behavioral Sciences and Mental Health, Iran University of Medical Sciences, Tehran, Iran.
Clin EEG Neurosci. 2025 Mar;56(2):140-149. doi: 10.1177/15500594241273125. Epub 2024 Aug 28.
Deficits in problem-solving may be related to vulnerability to suicidal behavior. We aimed to identify the electroencephalographic (EEG) power spectrum associated with the performance of the Raven as a reasoning/problem-solving task among individuals with recent suicide attempts. : This study with the case-control method, consisted of 61 participants who were assigned to three groups: Suicide attempt + Major Depressive Disorder (SA + MDD), Major Depressive Disorder (MDD), and Healthy Control (HC). All participants underwent clinical evaluations and problem-solving abilities. Subsequently, EEG signals were recorded while performing the Raven task. : The SA + MDD and MDD groups were significantly different from the HC group in terms of anxiety, reasons for life, and hopelessness. Regarding brain oscillations in performing the raven task, increased theta, gamma, and betha power extending over the frontal areas, including anterior prefrontal cortex, dlPFC, pre-SMA, inferior frontal cortex, and medial prefrontal cortex, was significant in SA + MDD compared with other groups. The alpha wave was more prominent in the left frontal, particularly in dlPFC in SA + MDD. Compared to the MDD group, the SA + MDD group had a shorter reaction time, while their response accuracy did not differ significantly. : Suicidal patients have more frontal activity in planning and executive function than the two other groups. Nevertheless, it seems that reduced activity in the left frontal region, which plays a crucial role in managing emotional distress, can contribute to suicidal tendencies among vulnerable individuals. The small sample size and chosen difficult trials for the Raven task were the most limitations of the study.
解决问题能力的缺陷可能与自杀行为的易感性有关。我们旨在确定与近期有自杀未遂经历的个体在完成瑞文推理/解决问题任务时相关的脑电图（EEG）功率谱。：本研究采用病例对照法，由61名参与者组成，他们被分为三组：自杀未遂+重度抑郁症（SA + MDD）组、重度抑郁症（MDD）组和健康对照组（HC）。所有参与者都接受了临床评估和解决问题能力测试。随后，在执行瑞文任务时记录脑电图信号。：SA + MDD组和MDD组在焦虑、生活理由和绝望感方面与HC组有显著差异。在执行瑞文任务时，SA + MDD组与其他组相比，额叶区域（包括前额叶前皮质、背外侧前额叶皮质、前辅助运动区、额下回皮质和内侧前额叶皮质）的θ波、γ波和β波功率增加显著。SA + MDD组的α波在左额叶更突出，特别是在背外侧前额叶皮质。与MDD组相比，SA + MDD组的反应时间更短，而反应准确性没有显著差异。：自杀患者在计划和执行功能方面的额叶活动比其他两组更多。然而，似乎在管理情绪困扰中起关键作用的左额叶区域活动减少可能导致易受伤害个体产生自杀倾向。本研究的最大局限性是样本量小以及为瑞文任务选择的试验难度大。
