Fallahinia Niloofar, Malakouti Seyed Kazem, Khosrowabadi Reza, Rasouli Nafee, Moradkhanie Shadi, Mahjoubnavaz Firouzeh, Bayat Masoumeh
Mental Health Research Center, Iran University of Medical Sciences, Tehran, Iran.
Geriatric Mental Health Research Center, School of Behavioral Sciences and Mental Health, Iran University of Medical Sciences, Tehran, Iran.
Psychiatry Res Neuroimaging. 2024 Dec;345:111912. doi: 10.1016/j.pscychresns.2024.111912. Epub 2024 Oct 20.
Our goal is to uncover Electroencephalography (EEG) power spectrum patterns during imagination tasks in individuals who attempted suicide within the past 1-4 weeks, addressing gaps in understanding the neural correlates of future imagination in suicidal behavior.
This case-control study comprised a total of 60 participants, consisting of 47 females and 13 males. The sample comprised three groups: Attempted Suicide + Major Depressive Disorder (SA+MDD), Major Depressive Disorder (MDD), and Healthy Controls (HC). To assess participants' future imagination, a unique approach called the Positive and Negative Future Imagination Task was designed, which involved scenario visualization concurrent with EEG recording. Statistical analyses included ANOVA with post-hoc pairwise comparisons to compare EEG power spectrum between three groups.
It was observed that the SA+MDD group experienced significantly increased theta frequency band in the right frontocentral regions when compared to the MDD group during both positive and negative imagination tasks (P-value < 0.05). Furthermore, increased gamma activity was observed in the SA+MDD group compared to the HC group, predominantly in the right frontocentral areas during both imagination tasks.
The results of this study indicate that individuals who have recently attempted suicide exhibit heightened neural activity in the frontocentral regions of the right hemisphere of the brain, specifically in theta and gamma band frequencies, when contemplating both positive and negative aspects of the future. These findings, in the context of behavioral tasks may indicate a decrease in the ability to envision a positive future and an increase in visualizing a negative future.
我们的目标是揭示过去1至4周内有自杀企图的个体在想象任务期间的脑电图（EEG）功率谱模式，以填补对自杀行为中未来想象的神经相关性理解方面的空白。
这项病例对照研究共有60名参与者，其中包括47名女性和13名男性。样本包括三组：自杀未遂+重度抑郁症（SA+MDD）、重度抑郁症（MDD）和健康对照组（HC）。为了评估参与者的未来想象力，设计了一种名为正负未来想象任务的独特方法，该方法涉及情景可视化并同时进行脑电图记录。统计分析包括方差分析及事后两两比较，以比较三组之间的脑电图功率谱。
观察到，与MDD组相比，SA+MDD组在正负想象任务期间右额中央区域的θ频段频率显著增加（P值<0.05）。此外，与HC组相比，SA+MDD组在两项想象任务期间γ活动增加，主要集中在右额中央区域。
本研究结果表明，最近有自杀企图的个体在思考未来的积极和消极方面时，大脑右半球额中央区域的神经活动增强，特别是在θ和γ频段频率上。在行为任务的背景下，这些发现可能表明设想积极未来的能力下降，而设想消极未来的能力增加。
