Terzaki Maria, Kouroupis Dimitrios, Zarras Charalampos, Molyvas Dimitrios, Michailidou Chrysi, Pateinakis Panagiotis, Mpani Konstantina, Soukiouroglou Prodromos, Paida Eleftheria, Simoulidou Elisavet, Chatzimichailidou Sofia, Petidis Konstantinos, Pyrpasopoulou Athina
2nd Propedeutic Department of Internal Medicine, Hippokration General Hospital Thessaloniki, 54642 Thessaloniki, Greece.
Microbiology Laboratory, Hippokration General Hospital Thessaloniki, 54642 Thessaloniki, Greece.
Diseases. 2024 Aug 20;12(8):190. doi: 10.3390/diseases12080190.
infection (CDI) has evolved to be the most significant cause of healthcare-associated diarrhoea and one of the leading representatives of healthcare-associated infections, with a high associated mortality. The aim of this retrospective study was to record the incidence rates and the epidemiological and clinical features of CDI in a large tertiary hospital of northern Greece in the years 2022-2023. All patients with CDI-compatible symptomatology and a positive CDI diagnostic test (GDH-glutamate dehydrogenase and toxin-positive FIA-Fluorescent Immuno-chromatography-SD Biosensor, and/or film array) were included (104 from a total of 4560 admitted patients). Their demographic, laboratory, and clinical data were recorded and analysed. The incidence of CDI in admitted patients was found to be higher than previous reports in the geographical area, reaching 54.6/10,000 patient days and following a rising trend over the course of the study. Thirty-day mortality was high (39.4%), potentially related to new emerging hypervirulent strains. In view of the high prevalence of multidrug-resistant organisms in the region, and the significant mortality associated with this infection, these findings particularly point to the need for the implementation of organized surveillance and infection prevention protocols.
艰难梭菌感染（CDI）已演变为医疗保健相关腹泻的最主要原因，也是医疗保健相关感染的主要代表之一，其相关死亡率很高。这项回顾性研究的目的是记录2022年至2023年希腊北部一家大型三级医院CDI的发病率以及流行病学和临床特征。纳入所有有CDI兼容症状且CDI诊断检测呈阳性（谷氨酸脱氢酶[GDH]和毒素阳性荧光免疫层析法[FIA] - SD生物传感器，和/或薄膜阵列）的患者（4560名入院患者中的104名）。记录并分析了他们的人口统计学、实验室和临床数据。发现入院患者中CDI的发病率高于该地理区域之前的报告，达到54.6/10000患者日，且在研究过程中呈上升趋势。30天死亡率很高（39.4%），可能与新出现的高毒力菌株有关。鉴于该地区多重耐药菌的高流行率以及这种感染相关的高死亡率，这些发现特别表明需要实施有组织的监测和感染预防方案。
