Isner J M, Michlewitz H, Clarke R H, Donaldson R F, Konstam M A, Salem D N
Am Heart J. 1985 Mar;109(3 Pt 1):448-52. doi: 10.1016/0002-8703(85)90546-0.
Experimental debridement of aortic valve calcium by means of laser phototherapy was investigated in vitro. Near-total debridement of calcific deposits observed on pretreatment x-ray films was accomplished using carbon-dioxide laser phototherapy. Analysis of liberated photoproducts suggests that debridement is effected by thermal degradation of the surrounding connective tissue envelope and thermal expansion of the calcific nodules. These results suggest that in selected patients with calcific aortic stenosis, it may be possible to perform intraoperative laser-assisted debridement of aortic valve calcium in order to preserve the native aortic valve and thus avoid prosthetic valve replacement.
通过激光光疗对主动脉瓣钙化进行实验性清创术的研究在体外展开。使用二氧化碳激光光疗实现了对预处理X线片上观察到的钙化沉积物的近乎完全清创。对释放出的光产物的分析表明，清创是由周围结缔组织包膜的热降解和钙化结节的热膨胀所导致的。这些结果表明，在选定的钙化性主动脉瓣狭窄患者中，有可能在术中进行激光辅助的主动脉瓣钙清创术，以保留天然主动脉瓣，从而避免人工瓣膜置换。
