Costa-Pereira Liliane Vanessa, Mendes Bruno Ferreira, Magalhães Caíque Olegário Diniz, Rodrigues Cíntia Maria, de Andrade Júllia Alves, de Pereira Ramona Ramalho Souza, Esteves Elizabethe Adriana, Cassilhas Ricardo Cardoso, Andrade Eric Francelino, Gripp Fernando, de Magalhães Flávio Castro, Sampaio Kinulpe Honorato, Improta-Caria Alex Cleber, Amorim Fabiano Trigueiro, Dias-Peixoto Marco Fabrício
Multicenter Graduate Program in Physiological Sciences, Brazilian Society of Physiology, Diamantina 39100-000, MG, Brazil.
Graduate Program in Health Sciences, Federal University of the Jequitinhonha and Mucuri Valleys, Diamantina 39100-000, MG, Brazil.
Metabolites. 2024 Aug 14;14(8):447. doi: 10.3390/metabo14080447.
Multiple short daily bouts of HIIT are more effective than single daily sessions in improving cardiometabolic and cellular adaptations in rats. We hypothesize that a short period of detraining is sufficient to abolish the superior adaptive responses to multiple versus single daily sessions of HIIT in rats. Male rats were divided into untrained, 1xHIIT, and 3xHIIT groups. Over eight weeks, the 1xHIIT group performed 115 min single daily sessions of HIIT, while the 3xHIIT group performed three 5 min sessions with 4 h intervals. After training, both groups remained sedentary for four weeks (detraining). Resting oxygen consumption (VO2), body composition, glucose/insulin tolerance, and blood pressure were recorded. After euthanasia, cardiac function/histology and gastrocnemius mitochondrial density were analyzed. After training, both 1xHIIT and 3xHIIT protocols induced similar improvements in VO2, maximal oxygen uptake (VO2max), cardiac function/hypertrophy, and gastrocnemius mitochondrial density. These effects were maintained even after detraining. Only the 3xHIIT protocol improved insulin sensitivity. After detraining, this effect was abolished. After training, both 1xHIIT and 3xHIIT protocols reduced adiposity. After detraining, the adiposity increased in both groups, with a more pronounced increase in the 3xHIIT rats. A four-week detraining period abolishes the superior adaptive responses to multiple versus single daily HIIT sessions in rats.
在改善大鼠心脏代谢和细胞适应性方面，每天多次进行短时间的高强度间歇训练（HIIT）比每天单次训练更有效。我们假设，短时间的停训足以消除大鼠对每天多次HIIT与每天单次HIIT的优越适应性反应。将雄性大鼠分为未训练组、单次HIIT组和三次HIIT组。在八周的时间里，单次HIIT组每天进行115分钟的单次HIIT训练，而三次HIIT组每天进行三次5分钟的训练，每次间隔4小时。训练后，两组均久坐不动四周（停训）。记录静息耗氧量（VO2）、身体成分、葡萄糖/胰岛素耐受性和血压。安乐死后，分析心脏功能/组织学和腓肠肌线粒体密度。训练后，单次HIIT组和三次HIIT组在VO2、最大摄氧量（VO2max）、心脏功能/肥大和腓肠肌线粒体密度方面均有相似的改善。即使在停训后，这些效果仍得以维持。只有三次HIIT方案改善了胰岛素敏感性。停训后，这种效果消失。训练后，单次HIIT组和三次HIIT组均降低了肥胖程度。停训后，两组的肥胖程度均增加，三次HIIT组大鼠的增加更为明显。四周的停训期消除了大鼠对每天多次HIIT与每天单次HIIT的优越适应性反应。
