College of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi'an 710119, China.
Ningxia Hui Autonomous Region Grain and Oil Product Quality Inspection Center, Yinchuan 750001, China.
Toxins (Basel). 2024 Aug 12;16(8):353. doi: 10.3390/toxins16080353.
Deoxynivalenol (DON) is a mycotoxin produced by widespread in wheat, corn, barley and other grain crops, posing the potential for being toxic to human and animal health, especially in the small intestine, which is the primary target organ for defense against the invasion of toxins. This study firstly investigated DON contamination in a local area of a wheat production district in China. Subsequently, the mechanism of DON toxicity was analyzed through cellular molecular biology combining with intestinal flora and gene transcription analysis; the results indicated that DON exposure can decrease IPEC-J2 cell viability and antioxidant capacity, stimulate the secretion and expression of proinflammatory factors, destroy the gut microbiota and affect normal functions of the body. It is illustrated that DON could induce intestinal damage through structural damage, functional injury and even intestinal internal environment disturbance, and, also, these intestinal toxicity effects are intrinsically interrelated. This study may provide multifaceted information for the treatment of intestinal injury induced by DON.
脱氧雪腐镰刀菌烯醇（DON）是一种广泛存在于小麦、玉米、大麦和其他谷物作物中的真菌毒素，可能对人类和动物健康造成潜在危害，尤其是在小肠中，小肠是防御毒素入侵的主要靶器官。本研究首先调查了中国小麦种植区局部地区的 DON 污染情况。随后，通过细胞分子生物学结合肠道菌群和基因转录分析研究了 DON 的毒性作用机制，结果表明 DON 暴露可降低 IPEC-J2 细胞活力和抗氧化能力，刺激促炎因子的分泌和表达，破坏肠道菌群并影响机体的正常功能。研究表明 DON 可通过结构损伤、功能损伤甚至肠道内环境紊乱诱导肠道损伤，而且这些肠道毒性作用内在相关。本研究可为 DON 诱导的肠道损伤的治疗提供多方面的信息。
