Cino Marzia, Gariboldi Elisa Maria, Stefanello Damiano, Spindler Kevin Pascal, Ferraris Erica Ilaria, Morello Emanuela Maria, Bertola Luca, Maniscalco Lorella, Martano Marina
Department of Veterinary Medical Sciences, University of Parma, Strada del Taglio 10, 43126 Parma, Italy.
Department of Veterinary Medicine and Animal Sciences, University of Milan, Via dell' Università 1, 26900 Lodi, Italy.
Vet Sci. 2023 Jul 5;10(7):436. doi: 10.3390/vetsci10070436.
Several studies evaluating Ki67 in canine cutaneous mast cell tumors (cMCTs) have reported its prognostic value when tumors of all histological grades are included. This study aims to evaluate whether the Ki67 index has a predictive value in a homogeneous cohort of G2/LG cMCTs with HN2 lymph nodes (LNs) and to describe the clinical outcome. The second goal was to explore the correlation between the Ki67 index and MC. The medical databases of three institutions were retrospectively searched for dogs undergoing surgical treatment for cMCT and LN extirpation, with a histological diagnosis of G2/LG with HN2 LNs. Information about histological margins, MC, Ki67 index, local recurrence, nodal relapse, distant metastasis, de novo cMCT occurrence and date and cause of death were included. A total of 39 cases were identified. None of these developed local and nodal relapse or metastatic distant disease. Median MC was 1 (0-2). Median Ki67 index was 3.5 (0.7-14.3). Ki67 and MC were not significantly correlated. At the end of the study, 32 (82%) dogs were alive, 7 (18%) dogs were dead from unrelated causes and 4 (10.2%) dogs were lost to follow-up. The median ST was not reached, and the mean was 893 days (104-2241 days). Considering the strict inclusion criteria, dogs affected by G2/LG with HN2 LNs treated with surgery alone may have a good oncologic outcome; the Ki67 index does not have prognostic impact.
多项评估犬皮肤肥大细胞瘤（cMCT）中Ki67的研究报告了其在纳入所有组织学分级肿瘤时的预后价值。本研究旨在评估Ki67指数在一组具有HN2淋巴结（LNs）的G2/LG cMCT同质队列中是否具有预测价值，并描述临床结果。第二个目标是探讨Ki67指数与肥大细胞（MC）之间的相关性。对三家机构的医学数据库进行回顾性检索，寻找接受cMCT手术治疗和LN切除且组织学诊断为G2/LG伴HN2 LNs的犬。纳入了有关组织学切缘、MC、Ki67指数、局部复发、淋巴结复发、远处转移、新发cMCT发生情况以及死亡日期和原因的信息。共确定了39例病例。这些病例均未发生局部和淋巴结复发或远处转移性疾病。MC中位数为1（0 - 2）。Ki67指数中位数为3.5（0.7 - 14.3）。Ki67与MC无显著相关性。研究结束时，32只（82%）犬存活，7只（18%）犬死于无关原因，4只（10.2%）犬失访。中位生存时间未达到，平均生存时间为893天（104 - 2241天）。考虑到严格的纳入标准，仅接受手术治疗的G2/LG伴HN2 LNs犬可能具有良好的肿瘤学结局；Ki67指数无预后影响。
