Liang Runyu, Zhu Luwen, Huang Yongyin, Chen Jia, Tang Qiang
Heilongjiang University of Chinese Medicine, Harbin, China.
Second Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, China.
Biogerontology. 2024 Nov;25(6):923-941. doi: 10.1007/s10522-024-10132-8. Epub 2024 Aug 28.
As one of the most vital organelles within biological cells, mitochondria hold an irreplaceable status and play crucial roles in various diseases. Research and therapies targeting mitochondria have achieved significant progress in numerous conditions. Throughout an organism's lifespan, mitochondrial dynamics persist continuously, and due to their inherent characteristics and various external factors, mitochondria are highly susceptible to damage. This susceptibility is particularly evident during aging, where the decline in biological function is closely intertwined with mitochondrial dysfunction. Despite being an ancient and enigmatic organelle, much remains unknown about mitochondria. Here, we will explore the past and present knowledge of mitochondria, providing a comprehensive review of their intrinsic properties and interactions with nuclear DNA, as well as the challenges and impacts they face during the aging process.
作为生物细胞内最重要的细胞器之一，线粒体具有不可替代的地位，并在各种疾病中发挥着关键作用。针对线粒体的研究和治疗在许多病症中都取得了显著进展。在生物体的整个生命周期中，线粒体动力学持续不断，并且由于其固有特性和各种外部因素，线粒体极易受到损伤。这种易损性在衰老过程中尤为明显，此时生物功能的衰退与线粒体功能障碍密切相关。尽管线粒体是一个古老而神秘的细胞器，但我们对它仍知之甚少。在这里，我们将探索线粒体的过去和现在的知识，全面综述其内在特性、与核DNA的相互作用，以及它们在衰老过程中面临的挑战和影响。
