Goldsmith J M, Kalish S B, Green D, Chmiel J S, Wallemark C B, Phair J P
Arch Intern Med. 1985 Mar;145(3):431-4.
We examined 35 patients with hemophilia to determine if there was an association between impaired cell-mediated immunity and the amount of factor concentrate use. There was a significant negative relationship between the logarithm of the helper-suppressor ratio and the logarithm of concentrate use determined over the previous one year, five years, and total lifetime. Similarly, the presence of splenomegaly was significantly associated with the logarithm of concentrate use for each time interval. Hypergammaglobulinemia, anergy, and lymphadenopathy were present in a high proportion of patients. Repeated study of 30 of these patients at eight to 14 months showed no significant changes in their T-cell subsets. At follow-up, 16 patients had lymphadenopathy with or without splenomegaly and four had splenomegaly alone. No significant associations between concentrate use during the study period and changes in T-cell subsets or clinical condition were found.
我们检查了35例血友病患者，以确定细胞介导免疫受损与凝血因子浓缩剂使用量之间是否存在关联。在前一年、五年和整个生命周期中，辅助性T细胞与抑制性T细胞比值的对数与凝血因子浓缩剂使用量的对数之间存在显著的负相关关系。同样，脾肿大的存在与每个时间间隔内凝血因子浓缩剂使用量的对数显著相关。高丙种球蛋白血症、无反应性和淋巴结病在很大一部分患者中存在。对其中30例患者在8至14个月时进行的重复研究显示，他们的T细胞亚群没有显著变化。随访时，16例患者有淋巴结病，伴或不伴脾肿大，4例患者仅有脾肿大。在研究期间，未发现凝血因子浓缩剂的使用与T细胞亚群变化或临床状况之间存在显著关联。
