Unzeitig J C, Church J A, Gomperts E D, Nye C A, Pasquale S, Richards W
Am J Dis Child. 1984 Jul;138(7):645-8. doi: 10.1001/archpedi.1984.02140450027008.
The acquired immune deficiency syndrome (AIDS) has been reported in hemophiliacs . We examined lymphocyte numbers and functions in 28 patients with hemophilia and 16 healthy adults. Healthy hemophiliacs who had received fewer than 150 commercial factor concentrate (CFC) infusions had normal T-cell numbers, T-cell subsets, and mitogen responses. Healthy hemophiliacs who had received more than 250 CFC infusions had a decreased number of Leu 3+ "helper" T cells, a decreased Leu 3-Leu 2 ratio, and decreased pokeweed mitogen responses. Hemophiliacs who had received greater than 250 CFC infusions and who had persistent lymphadenopathy had decreased Leu 3+ cells, increased Leu 2+ "suppressor" T cells, a decreased Leu 3-Leu 2 ratio, and decreased phytohemagglutinin responses. Abnormal results of T-cell studies were found in 67% of healthy hemophiliacs who had a high degree of CFC exposure and 100% of clinically abnormal hemophiliacs. These findings suggest that hemophiliacs are at risk for the development of the immunologic changes that characterize AIDS and that this risk is related to CFC exposure.
血友病患者中已报告有获得性免疫缺陷综合征（艾滋病）。我们检查了28例血友病患者和16名健康成年人的淋巴细胞数量及功能。接受少于150次商业浓缩因子（CFC）输注的健康血友病患者的T细胞数量、T细胞亚群及丝裂原反应正常。接受超过250次CFC输注的健康血友病患者的Leu 3+“辅助性”T细胞数量减少，Leu 3-Leu 2比值降低，商陆丝裂原反应减弱。接受超过250次CFC输注且有持续性淋巴结病的血友病患者的Leu 3+细胞减少，Leu 2+“抑制性”T细胞增加，Leu 3-Leu 2比值降低，植物血凝素反应减弱。在CFC暴露程度高的健康血友病患者中，67%的T细胞研究结果异常，而临床异常的血友病患者中这一比例为100%。这些发现提示，血友病患者有发生具有艾滋病特征的免疫改变的风险，且这种风险与CFC暴露有关。
